2H-1-Benzopyran-3-carboxylic acid, 3,4-dihydro-6-Methoxy-, (3S)-

Base Information

• Chemical Name: 2H-1-Benzopyran-3-carboxylic acid, 3,4-dihydro-6-Methoxy-, (3S)-
• CAS No.: 182570-28-1
• Molecular Formula: C11 H12O4
• Molecular Weight: 208.21058
• Mol file: 182570-28-1.mol

Synonyms:QC-3248;

Chemical Property of 2H-1-Benzopyran-3-carboxylic acid, 3,4-dihydro-6-Methoxy-, (3S)-

Chemical Property:

• PSA: 55.76000
• LogP: 1.33090
• Storage Temp.: 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

(S)-6-Methoxychroman-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-1-Benzopyran-3-carboxylic acid, 3,4-dihydro-6-Methoxy-, (3S)-

There total 6 articles about 2H-1-Benzopyran-3-carboxylic acid, 3,4-dihydro-6-Methoxy-, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.3%

6-methoxy-3,4-dihydro-2H-1-benzopyran-3-carboxylic acid (182570-26-9) → (S)-6-methoxychroman-3-carboxylic acid (182570-28-1) + (R)-6-methoxychroman-3-carboxylic acid

Guidance literature:

With (1R,2R)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol; In methanol; acetonitrile;

Reference yield: 36.8%

(S)-6-methoxychroman-3-carboxylic acid (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol salt → (S)-6-methoxychroman-3-carboxylic acid (182570-28-1)

Guidance literature:

In water; ethyl acetate;

Reference yield: 36.0%

6-methoxy-3,4-dihydro-2H-1-benzopyran-3-carboxylic acid (182570-26-9) → (S)-6-methoxychroman-3-carboxylic acid (182570-28-1)

Guidance literature:

With (1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol; In acetonitrile; for 0.5h; Resolution of racemate; Reflux;

DOI:10.1016/j.bmc.2019.02.047

upstream raw materials:

6-methoxy-3,4-dihydro-2H-1-benzopyran-3-carboxylic acid

3-caboxy-6-methoxy-2H-1-benzopyran

2-hydroxy-5-methoxybenzaldehyde

6-methoxy-2H-chromene-3-carbonitrile

Refernces

• 1、 -. "Preparation method of optically pure (R)-6-methoxychroman-3-carboxylic acid". Paragraph 0043-0047; 0049; 0050-0052. . Retrieved 2018/10/04.