2-Bromo-4,6-difluorobenzothiazole

Base Information

• Chemical Name: 2-Bromo-4,6-difluorobenzothiazole
• CAS No.: 1019117-36-2
• Molecular Formula: C7H2BrF2NS
• Molecular Weight: 250.0632864
• Hs Code.: 29342000
• Mol file: 1019117-36-2.mol

Synonyms:2-BROMO-4,6-DIFLUOROBENZOTHIAZOLE;2-broMo-4,6-difluorobenzo[d]thiazole

Chemical Property of 2-Bromo-4,6-difluorobenzothiazole

Chemical Property:

• Boiling Point: 294.1±43.0 °C(Predicted)
• PKA: -1.86±0.10(Predicted)
• PSA: 41.13000
• Density: 1.910±0.06 g/cm3(Predicted)
• LogP: 3.33700

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4,6-difluorobenzo[d]thiazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4,6-difluorobenzothiazole

There total 2 articles about 2-Bromo-4,6-difluorobenzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4,6-dimethoxybenzo[d]thiazol-2-amine (65948-18-7) → 2-bromo-4,6-difluorobenzo[d]thiazole (1019117-36-2)

Guidance literature:

With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 50 ℃; for 0.666667h;

Reference yield: 68.0%

2-amino-4,6-difluoro-benzothiazole (119256-40-5) → 2-bromo-4,6-difluorobenzo[d]thiazole (1019117-36-2)

Guidance literature:

With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.201900356

upstream raw materials:

2-amino-4,6-difluoro-benzothiazole

4,6-dimethoxybenzo[d]thiazol-2-amine

Refernces

• 1、 -. "BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS". Page/Page column 681; 682. . Retrieved 2018/03/25.