MOEXIPRILAT HYDRATE

Base Information

• Chemical Name: MOEXIPRILAT HYDRATE
• CAS No.: 103775-14-0
• Molecular Formula: C25H30 N2 O7
• Molecular Weight: 470.522
• Hs Code.: 2933497050
• Mol file: 103775-14-0.mol

Synonyms:3-Isoquinolinecarboxylicacid,2-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-,[3S-[2[R*(R*)],3R*]]-; Moexiprilat; RS 10029

Chemical Property of MOEXIPRILAT HYDRATE

Chemical Property:

• Vapor Pressure: 1.34E-21mmHg at 25°C
• Melting Point: 145-1700C
• Boiling Point: 717.4°Cat760mmHg
• Flash Point: 387.7°C
• PSA: 125.40000
• Density: 1.284g/cm³
• LogP: 2.43460
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Purity/Quality:

99% ^*data from raw suppliers

Moexiprilat ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Analogue of Quinapril Angiotensin converting enzyme (ACE) inhibitor; dimethoxy analog of Quinapril. Antihypertensive. Moexiprilat is an angiotensin converting enzyme (ACE) inhibitor; dimethoxy analog of Quinapril. Antihypertensive.

Technology Process of MOEXIPRILAT HYDRATE

There total 3 articles about MOEXIPRILAT HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

moexipril hydrochloride (82586-52-5) → Moexiprilat (103775-14-0)

Guidance literature:

With sodium hydroxide; water; In methanol; Ambient temperature;

DOI:10.1021/jm00160a026

Reference yield:

<3S-<2>,3R*>-2-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>amino>-1-oxopropyl>-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid, phenylmethyl ester, hydrochloride (82586-51-4) → Moexiprilat (103775-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / H₂ / Pd/C / tetrahydrofuran

2: 80 percent / NaOH, H₂O / methanol / Ambient temperature

With sodium hydroxide; water; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jm00160a026

Reference yield:

moexipril hydrochloride (82586-52-5) → Moexiprilat (103775-14-0) + 2-(8,9-dimethoxy-3-methyl-1,4-dioxo-1,3,4,6,11,11a-hexahydro-pyrazino[1,2-b]isoquinolin-2-yl)-4-phenyl-butyric acid ethyl ester

Guidance literature:

at 89.85 ℃; Further Variations:; Temperatures; humidity; Kinetics; Activation energy; Thermodynamic data;

upstream raw materials:

moexipril hydrochloride

<3S-<2>,3R*>-2-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>amino>-1-oxopropyl>-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid, phenylmethyl ester, hydrochloride

Refernces

• 1、 Klutchko,Blankley,Fleming,Hinkley,Werner,Nordin,Holmes,Hoefle,Cohen,Essenburg. "Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types". . p. 1953 - 1961. Retrieved 2007/10/02.