3,5-DiMethyl-1-nitroadaMantane

Base Information

• Chemical Name: 3,5-DiMethyl-1-nitroadaMantane
• CAS No.: 6588-68-7
• Molecular Formula: C12H19NO2
• Molecular Weight: 209.288
• Hs Code.: 2904209090
• Mol file: 6588-68-7.mol

Synonyms:3,5-Dimethyl-1-nitroadamantane;

Chemical Property of 3,5-DiMethyl-1-nitroadaMantane

Chemical Property:

• Boiling Point: 278.275 °C at 760 mmHg
• Flash Point: 109.707 °C
• PSA: 45.82000
• Density: 1.134 g/cm³
• LogP: 3.53530
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

99%, ^*data from raw suppliers

1,3-Dimethyl-5-nitroadamantane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,3-Dimethyl-5-nitroadamantane is a potential neuroprotective agent which may aid in the treatment of neurodegenerative disorders such as parkinsons.

Technology Process of 3,5-DiMethyl-1-nitroadaMantane

There total 4 articles about 3,5-DiMethyl-1-nitroadaMantane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,3-dimethyladamantane (702-79-4) → 1-nitro-3,5-dimethyl-adamantane (6588-68-7)

Guidance literature:

With N-hydroxyphthalimide; air; Nitrogen dioxide; In various solvent(s); at 70 ℃; for 14h; under 760 Torr;

DOI:10.1002/1521-3773(20010105)40:1<222::AID-ANIE222>3.0.CO;2-W

Reference yield: 60.0%

N-hydroxyphthalimide (524-38-9) + 1,3-dimethyladamantane (702-79-4) + α,α,α-trifluorotoluene (98-08-8) → 1-nitro-3,5-dimethyl-adamantane (6588-68-7)

Guidance literature:

With Nitrogen dioxide;

Reference yield:

1,3-dimethyladamantane (702-79-4) → 1,3-dimethyl-5-adamantanol (707-37-9) + 1-nitro-3,5-dimethyl-adamantane (6588-68-7)

Guidance literature:

With nitric acid; acetic acid; [H₄PVMo₁₁O₄₀]; at 82.85 ℃; under 760 Torr; Title compound not separated from byproducts;

DOI:10.1002/chem.200400049

upstream raw materials:

1,3-dimethyladamantane

N-hydroxyphthalimide

α,α,α-trifluorotoluene

Downstream raw materials:

memantine hydrochloride

Refernces

• 1、 Shinachi, Satoshi,Yahiro, Hidenori,Yamaguchi, Kazuya,Mizuno, Noritaka. "Nitration of alkanes with nitric acid by vanadium-substituted polyoxometalates". . p. 6489 - 6496. Retrieved 2007/10/03.
• 2、 Sakaguchi, Satoshi,Nishiwaki, Yoshiki,Kitamura, Takaaki,Ishii, Yasutaka. "Efficient Catalytic Alkane Nitration with NO2 under Air Assisted by N-Hydroxyphthalimide". . p. 222 - 224. Retrieved 2007/10/03.