Morpholin-4-yl-acetaldehyde, diMethyl acetal

Base Information

• Chemical Name: Morpholin-4-yl-acetaldehyde, diMethyl acetal
• CAS No.: 22633-57-4
• Molecular Formula: C8H17NO3
• Molecular Weight: 175.23
• Hs Code.: 2934999090
• Mol file: 22633-57-4.mol

Synonyms:Morpholin-4-yl-acetaldehyde, diMethyl acetal

Chemical Property of Morpholin-4-yl-acetaldehyde, diMethyl acetal

Chemical Property:

• Boiling Point: 81.5-83 °C(Press: 5 Torr)
• PKA: 7.16±0.10(Predicted)
• PSA: 30.93000
• Density: 1.017±0.06 g/cm3(Predicted)
• LogP: -0.12460
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-(2,2-Dimethoxyethyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morpholin-4-yl-acetaldehyde, diMethyl acetal

There total 4 articles about Morpholin-4-yl-acetaldehyde, diMethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

morpholine (110-91-8,99108-56-2) + dimethoxyacetaldehyde (51673-84-8) → 4-(2,2-dimethoxyethyl)morpholine (22633-57-4)

Guidance literature:

morpholine; dimethoxyacetaldehyde; With acetic acid; In methanol; water; at 20 ℃; for 3h;

With sodium cyanoborohydride; In methanol; water; at 20 ℃; for 16h;

Reference yield:

morpholine (110-91-8,99108-56-2) + 1-bromo-2,2-dimethoxyethane (7252-83-7) → 4-(2,2-dimethoxyethyl)morpholine (22633-57-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 16h;

DOI:10.1021/jm5014659

Reference yield:

morpholine (110-91-8,99108-56-2) + chloroacetaldehyde dimethyl acetal (97-97-2) → 4-(2,2-dimethoxyethyl)morpholine (22633-57-4)

Guidance literature:

DOI:10.1021/ja01174a604

upstream raw materials:

morpholine

chloroacetaldehyde dimethyl acetal

1-bromo-2,2-dimethoxyethane

dimethoxyacetaldehyde

Downstream raw materials:

morpholin-4-yl-acetaldehyde hydrochloride

(Z)-(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-2-fluoro-4-morpholinobut-2-enamide

(E)-(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-2-fluoro-4-morpholinobut-2-enamide

(Z)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-fluoro-4-morpholinobut-2-enamide

Refernces

• 1、 OuYang, Yiqiang,Zou, Wensheng,Peng, Liang,Yang, Zunhua,Tang, Qidong,Chen, Mengzi,Jia, Shuang,Zhang, Hong,Lan, Zhou,Zheng, Pengwu,Zhu, Wufu. "Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline as potential EGFR inhibitors". . p. 29 - 43. Retrieved 2018/05/24.