(1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-(MethoxyMethoxy)-5,6-diMethylhept-3-en-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diol

Base Information

• Chemical Name: (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-(MethoxyMethoxy)-5,6-diMethylhept-3-en-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diol
• CAS No.: 1023889-38-4
• Molecular Formula: C29H48O4
• Molecular Weight: 460.69
• Mol file: 1023889-38-4.mol

Synonyms:(1R,3R)-5 - ((E)-2 - ((1R,3AS,7AR)-1 - ((2R,5S,E)-;(1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-(methoxymethoxy)-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)cyclohexane-1,3-diol;1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-(methoxymethoxy)-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R)-;(1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-(MethoxyMethoxy)-5,6-diMethylhept-3-en-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diol

Chemical Property of (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-(MethoxyMethoxy)-5,6-diMethylhept-3-en-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diol

Chemical Property:

• PSA: 58.92000
• LogP: 6.18880

Purity/Quality:

99% ^*data from raw suppliers

(1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-(methoxymethoxy)-5,6-dimethylhept-3-en-2-yl)-7a-methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-(MethoxyMethoxy)-5,6-diMethylhept-3-en-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diol

There total 2 articles about (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-(MethoxyMethoxy)-5,6-diMethylhept-3-en-2-yl)-7a-Methyldihydro-1H-inden-4(2H,5H,6H,7H,7aH)-ylidene)ethylidene)cyclohexane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H50O5 (1023889-37-3) + C31H50O5 (1023889-36-2) → 1α-hydroxy-25-methoxymethyloxy-19-norvitamin D2 (1023889-38-4)

Guidance literature:

C₃₁H₅₀O₅; C₃₁H₅₀O₅; With potassium hydroxide; In ethanol; at 0 ℃; for 1h;

With water; In ethanol;

Reference yield:

C30H50O4 (1023889-35-1) → 1α-hydroxy-25-methoxymethyloxy-19-norvitamin D2 (1023889-38-4)

Guidance literature:

C₃₀H₅₀O₄; With acetic acid; at 60 ℃; for 0.333333h;

With water; potassium hydroxide; In ethanol; at 0 ℃; for 1h;

DOI:10.1016/j.tet.2009.09.115

Reference yield:

1α-hydroxy-25-methoxymethyloxy-19-norvitamin D2 (1023889-38-4) → paricalcitol (131918-61-1)

Guidance literature:

With camphor-10-sulfonic acid; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 3h; Product distribution / selectivity;

upstream raw materials:

C₃₁H₅₀O₅

C₃₁H₅₀O₅

C₃₀H₅₀O₄

Downstream raw materials:

paricalcitol

Refernces

• 1、 Toyoda, Asako,Nagai, Hazuki,Yamada, Tomonari,Moriguchi, Yusuke,Abe, Junko,Tsuchida, Toshio,Nagasawa, Kazuo. "Novel synthesis of 1α,25-dihydroxy-19-norvitamin D from 25-hydroxyvitamin D". experimental part. p. 10002 - 10008. Retrieved 2010/02/27.