1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester
• CAS No.: 374795-42-3
• Molecular Formula: C14H25NO4
• Molecular Weight: 271.357
• Mol file: 374795-42-3.mol

Synonyms:tert-Butyl-3-hydroxy-1-oxa-9-azaspiro[5.5]undecan-9-carboxylat

Chemical Property of 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 399.798°C at 760 mmHg
• Flash Point: 195.591°C
• PSA: 59.00000
• Density: 1.145g/cm³
• LogP: 1.86530

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Oxa-9-azaspiro[5.5]undecane-9-carboxylicacid,3-hydroxy-,1,1-dimethylethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester

There total 7 articles about 1-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate (374795-40-1) → tert-butyl 3-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate (374795-42-3)

Guidance literature:

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate; With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 24h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 24.0%

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate (374795-40-1) → tert-butyl 3-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate (374795-42-3) + tert-butyl 4-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate (374796-29-9)

Guidance literature:

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate; With borane; In tetrahydrofuran; at 20 ℃; for 6.5h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

Reference yield:

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate → tert-butyl 3-hydroxy-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate (374795-42-3)

Guidance literature:

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate; With borane-THF; In tetrahydrofuran; for 4h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

tert-butyl 1-oxa-9-azaspiro[5.5]undec-3-ene-9-carboxylate

1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine

tert-butyl 4-allyl-4-(allyloxy)piperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

tert-butyl 3-oxo-1-oxa-9-azaspiro[5.5]undecane-9-carboxylate

Refernces

• 1、 -. "SPIROCYCLIC COMPOUNDS". Page/Page column 69. . Retrieved 2012/02/02.
• 2、 -. "Cyclohexane derivatives and their use as therapeutic agents". Page 36. . Retrieved 2010/02/06.