ONO 7643 FuMarate

Base Information

• Chemical Name: ONO 7643 FuMarate
• CAS No.: 339539-92-3
• Molecular Formula: C31H42N6O3.C4H4O4
• Molecular Weight: 662.77600
• Mol file: 339539-92-3.mol

Synonyms:RC1291 Fumarate;ONO7643 Fumarate;Anamorelin Fumarate;Anamorelin Fumarate||ONO-7643 Fumarate|RC1291 Fumarate|ONO7643 Fumarate|RC 1291 Fumarate|ONO 7643 Fumarate;CS-1076;

Chemical Property of ONO 7643 FuMarate

Chemical Property:

• PSA: 192.86000
• LogP: 3.90930

Purity/Quality:

98% ^*data from raw suppliers

Anamorelinfumarate >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ONO 7643 FuMarate

There total 11 articles about ONO 7643 FuMarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{1-[(1R)-2-[(3R)-3-benzyl-3-(N,N',N'-trimethylhydrazinocarbonyl)piperidin-1-yl]-1-(1H-indol-3-ylmethyl)-2-oxo-ethylcarbamoyl]-1-methylethyl}carbamic acid tert-butyl ester (883572-59-6) + {1-[(1R)-2-](3R)-3-Benzyl-3-(N,N',N'-trimethylhydrazinocarbonyl)piperidin-1-yl-9-1-(1H-indol-3-ylmethyl)-2-oxo-ethyicarbamoyl]-1-methylethyl}carbamic acid tert-butyl ester + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) → 2-Amino-N-[(1R)-2-[(3S)-3-benzyl-3-(N,N',N'-trimethylhydrazinocarbonyl)piperidin-1-yl]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]2-methylpropionamide, fumarate (339539-93-4,339539-92-3)

Guidance literature:

With sodium carbonate; In dichloromethane; water; ethyl acetate; isopropyl alcohol;

Reference yield:

(R)-2-(2-tert-Butoxycarbonylamino-2-methyl-propionylamino)-3-(1H-indol-3-yl)-propionic acid (159634-94-3) → RC-1291 fumarate (339539-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 3-hydroxy-3,4-dihydrobenzotriazine-4-one; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / ethyl acetate

3.1: sodium carbonate / dichloromethane

With hydrogenchloride; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In dichloromethane; ethyl acetate;

DOI:10.1021/op0502506

Reference yield:

D-tryptophan (153-94-6,27732-43-0,80206-30-0,27813-82-7) → RC-1291 fumarate (339539-92-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 38 °C

2.1: 3-hydroxy-3,4-dihydrobenzotriazine-4-one; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / ethyl acetate

4.1: sodium carbonate / dichloromethane

With hydrogenchloride; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In dichloromethane; ethyl acetate;

DOI:10.1021/op0502506

upstream raw materials:

{1-[(1R)-2-[(3R)-3-benzyl-3-(N,N',N'-trimethylhydrazinocarbonyl)piperidin-1-yl]-1-(1H-indol-3-ylmethyl)-2-oxo-ethylcarbamoyl]-1-methylethyl}carbamic acid tert-butyl ester

(2E)-but-2-enedioic acid

Boc-D-Trp-OH

C₁₆H₂₅N₃O*2ClH

Refernces

• 1、 -. "Compound with growth hormone releasing properties". . . Retrieved 2008/06/13.