Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-

Base Information

• Chemical Name: Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-
• CAS No.: 1169558-38-6
• Molecular Formula: C14H12ClN3O2
• Molecular Weight: 289.72
• Mol file: 1169558-38-6.mol

Synonyms:0SX;8-Chloro-2-[(2s)-Pyrrolidin-2-Yl][1]benzofuro[3,2-D]pyrimidin-4(3h)-One;(S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one;Benzofuro(3,2-d)pyrimidin-4(3H)-one,8-chloro-2-((2S)-2-pyrrolidinyl);UNII-8QK62S7492;

Chemical Property of Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-

Chemical Property:

• PKA: 8.38±0.20(Predicted)
• PSA: 71.18000
• Density: 1.69±0.1 g/cm3(Predicted)
• LogP: 3.48830

Purity/Quality:

98%min ^*data from raw suppliers

8-Chloro-2-[(2S)-pyrrolidin-2-yl]-1H-[1]benzofuro[3,2-d]pyrimidin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-

There total 6 articles about Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H14ClN3O3 (1169749-58-9) → XL413 (1169558-38-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 85 ℃;

DOI:10.1016/j.bmcl.2012.04.024

Reference yield:

C9H7ClN2O2 (1169561-46-9) → XL413 (1169558-38-6)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 85 °C

2: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl acetamide / 0 - 20 °C

3: hydrogenchloride / 1,4-dioxane

4: sodium hydroxide / ethanol / 85 °C

With hydrogenchloride; 1,3,5-trichloro-2,4,6-triazine; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.04.024

Reference yield:

3-amino-5-chlorobenzofuran-2-carboxamide (294878-00-5) → XL413 (1169558-38-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl acetamide / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane

3: sodium hydroxide / ethanol / 85 °C

With hydrogenchloride; 1,3,5-trichloro-2,4,6-triazine; sodium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide;

DOI:10.1016/j.bmcl.2012.04.024

upstream raw materials:

C₁₄H₁₄ClN₃O₃

C₉H₇ClN₂O₂

3-amino-5-chlorobenzofuran-2-carboxamide

1-(tert-butoxycarbonyl)-L-proline

Refernces