(S)-(+)-1-METHOXY-2-PROPANOL

Base Information

• Chemical Name: (S)-(+)-1-METHOXY-2-PROPANOL
• CAS No.: 116422-39-0
• Molecular Formula: C4H10 O2
• Molecular Weight: 90.1222
• Hs Code.: 2909499000
• Mol file: 116422-39-0.mol

Synonyms:1-Propanol,2-methoxy-, (S)-; (2S)-2-Methoxypropan-1-ol; (S)-2-Methoxy-1-propanol;(S)-2-Methoxypropanol

Chemical Property of (S)-(+)-1-METHOXY-2-PROPANOL

Chemical Property:

• Vapor Pressure: 4.44mmHg at 25°C
• Melting Point: -84.2°C (estimate)
• Refractive Index: n20/D 1.403
• Boiling Point: 118 ºC
• PKA: 14.44±0.10(Predicted)
• Flash Point: 33 ºC
• PSA: 29.46000
• Density: 0.938
• LogP: 0.01360
• Storage Temp.: Flammables area

Purity/Quality:

99% ^*data from raw suppliers

(2S)-2-Methoxy-1-propanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R10:
• Hazard Codes: R10:
• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2S)-2-Methoxy-1-propanol can be used as DNA-dependent protein kinase inhibitors to treat diseases.

Technology Process of (S)-(+)-1-METHOXY-2-PROPANOL

There total 2 articles about (S)-(+)-1-METHOXY-2-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (R)-propylene oxide (15448-47-2) → (S)-1-Methoxy-propan-2-ol (26550-55-0) + (R)-1-methoxy-2-propanol (4984-22-9) + (S)-(+)-2-methoxypropanol (116422-39-0) + (2R)-2-methoxypropan-1-ol (6131-59-5) + (S)-(+)-1,2-dimethoxypropane (76946-23-1) + (R)-(-)-1,2-dimethoxypropane (76946-22-0)

Guidance literature:

With Methyl fluoride; at 25 ℃; under 720 Torr; Product distribution; Mechanism; Irradiation; also in the presence of H₂O or CH₄;

DOI:10.1002/chem.19970031223

Reference yield:

methanol (67-56-1) + (S)-Propylene oxide (16088-62-3) → (S)-1-Methoxy-propan-2-ol (26550-55-0) + (R)-1-methoxy-2-propanol (4984-22-9) + (S)-(+)-2-methoxypropanol (116422-39-0) + (2R)-2-methoxypropan-1-ol (6131-59-5) + (S)-(+)-1,2-dimethoxypropane (76946-23-1) + (R)-(-)-1,2-dimethoxypropane (76946-22-0)

Guidance literature:

With Methyl fluoride; at 25 ℃; under 720 Torr; Product distribution; Mechanism; Irradiation; also in the presence of H₂O or CH₄;

DOI:10.1002/chem.19970031223

Reference yield: 85.0%

(S)-(+)-2-methoxypropanol (116422-39-0) + dichloromethylphenylsilane (149-74-6) → bis(2-methoxypropoxy)methylphenylsilane (193333-27-6)

Guidance literature:

With pyridine; In benzene; at 70 - 80 ℃; for 3h;

DOI:10.1246/bcsj.70.1393

upstream raw materials:

methanol

(R)-propylene oxide

(S)-Propylene oxide

Downstream raw materials:

toluene-4-sulfonic acid 2-methoxy-2-methylethyl ester

bis(2-methoxypropoxy)methylphenylsilane

tert-butyl [1-(4-{[(2S)-2-methoxypropyl]oxy}phenyl)ethyl]carbamate

(3aR,7S,7aS)-3-(3-isopropyl-benzyl)-7-[3-((S)-2-methoxy-propoxymethyl)-benzyl]-5,5-dioxo-hexahydro-1-oxa-5λ6-thia-3-aza-inden-2-one

Refernces