3-(ChloroMethyl)pyridazine hydrochloride

Base Information

• Chemical Name: 3-(ChloroMethyl)pyridazine hydrochloride
• CAS No.: 27349-66-2
• Molecular Formula: C5H6Cl2N2
• Molecular Weight: 165.022
• Hs Code.: 2933990090
• Mol file: 27349-66-2.mol

Synonyms:pyridazine, 3-(chloromethyl)-; 3-(chloromethyl)pyridazine hydrochloride

Chemical Property of 3-(ChloroMethyl)pyridazine hydrochloride

Chemical Property:

• Vapor Pressure: 0.00577mmHg at 25°C
• Boiling Point: 282.3°C at 760 mmHg
• Flash Point: 151.6°C
• PSA: 25.78000
• Density: 1.241g/cm³
• LogP: 2.01740
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(chloromethyl)pyridazinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(ChloroMethyl)pyridazine hydrochloride

There total 7 articles about 3-(ChloroMethyl)pyridazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-hydroxymethylpyridazine (37444-46-5) → 3-(chloromethyl)pyridazine hydrochloride (27349-66-2)

Guidance literature:

With thionyl chloride; at 20 ℃; for 0.75h; Cooling with ice;

DOI:10.1002/ejic.201800533

Reference yield: 80.0%

3-methylpyridazine (1632-76-4) + trichloroisocyanuric acid (87-90-1) → 3-(chloromethyl)pyridazine hydrochloride (27349-66-2)

Guidance literature:

In chloroform; Reflux;

Reference yield:

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) → 3-(chloromethyl)pyridazine hydrochloride (27349-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; bromine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 48 h / 20 °C

2.1: sulfuric acid / 0.02 h / Heating

2.2: 0.33 h / Heating

3.1: thionyl chloride / 0.75 h / 20 °C / Cooling with ice

With thionyl chloride; sulfuric acid; bromine; sodium hydrogencarbonate; In diethyl ether;

DOI:10.1002/ejic.201800533

upstream raw materials:

3-hydroxymethylpyridazine

3-methylpyridazine

trichloroisocyanuric acid

(2-furyl)methyl alcohol

Refernces

• 1、 -. "SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS". Page/Page column 103. . Retrieved 2018/04/23.
• 2、 -. "Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction". . . Retrieved 2008/06/13.