Cyclopenta[c]pyrrole-1,2(1H)-dicarboxylic acid, hexahydro-, 2-(1, 1-dimethylethyl) 1-ethyl ester, (1S,3aR,6aS)-.

Base Information

• Chemical Name: Cyclopenta[c]pyrrole-1,2(1H)-dicarboxylic acid, hexahydro-, 2-(1, 1-dimethylethyl) 1-ethyl ester, (1S,3aR,6aS)-.
• CAS No.: 1053232-60-2
• Molecular Formula: C15 H25NO4
• Molecular Weight: 283.368
• Mol file: 1053232-60-2.mol

Synonyms:

Chemical Property of Cyclopenta[c]pyrrole-1,2(1H)-dicarboxylic acid, hexahydro-, 2-(1, 1-dimethylethyl) 1-ethyl ester, (1S,3aR,6aS)-.

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopenta[c]pyrrole-1,2(1H)-dicarboxylic acid, hexahydro-, 2-(1, 1-dimethylethyl) 1-ethyl ester, (1S,3aR,6aS)-.

There total 13 articles about Cyclopenta[c]pyrrole-1,2(1H)-dicarboxylic acid, hexahydro-, 2-(1, 1-dimethylethyl) 1-ethyl ester, (1S,3aR,6aS)-. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(1S,3aR,6aS)-ethyl 2-boc-4-(phenoxycarbonothioyloxy)octahydrocyclopenta[c]pyrrole-1-carboxylate (1053232-59-9) → (1S,3aR,6aS)-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester (1053232-60-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 4h; Reflux; Inert atmosphere;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride → (1S,3aR,6aS)-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester (1053232-60-2)

Guidance literature:

octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride; With lipase from Aspergillus niger; In aq. phosphate buffer; at 30 ℃; for 24h; pH=7; Enzymatic reaction;

di-tert-butyl dicarbonate; With sodium hydroxide; In ethyl acetate; at 20 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester hydrochloride → (1S,3aR,6aS)-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester (1053232-60-2)

Guidance literature:

hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester hydrochloride; With lipase from Aspergillus niger; In aq. phosphate buffer; at 30 ℃; for 24h; pH=7; Enzymatic reaction;

di-tert-butyl dicarbonate; With sodium hydroxide; In aq. phosphate buffer; ethyl acetate; at 20 ℃;

upstream raw materials:

(1S,3aR,6aS)-ethyl 2-boc-4-(phenoxycarbonothioyloxy)octahydrocyclopenta[c]pyrrole-1-carboxylate

(3aR,6aS)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole

di-tert-butyl dicarbonate

(1SR,3aRS,6aSR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

Downstream raw materials:

(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF A VIRAL PROTEASE INHIBITOR AND INTERMEDIATES THEREOF". . . Retrieved 2014/11/11.
• 2、 -. "TERTIARY AMINE SUBSTITUTED PEPTIDES USEFUL AS INHIBITORS OF HCV REPLICATION". Page/Page column 17. . Retrieved 2010/12/18.