Ponatinib tris-hydrochloride

Base Information

• Chemical Name: Ponatinib tris-hydrochloride
• CAS No.: 1232836-25-7
• Molecular Formula: C29H30Cl3F3N6O
• Molecular Weight: 641.94
• Mol file: 1232836-25-7.mol

Synonyms:AP24534 tris-hydrochloride;Ponatinib tris-hydrochloride;3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide trishydrochloride

Chemical Property of Ponatinib tris-hydrochloride

Chemical Property:

• PSA: 65.77000
• LogP: 6.81080

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ponatinib tris-hydrochloride

There total 9 articles about Ponatinib tris-hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ponatinib (943319-70-8) → 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide hydrochloride (1232836-25-7)

Guidance literature:

With hydrogenchloride; In ethanol; acetonitrile; at 50 ℃;

Reference yield:

ponatinib (943319-70-8) → Ponatinib Hydrochloride (1232836-25-7)

Guidance literature:

With hydrogenchloride; In ethanol; at 60 - 70 ℃;

Reference yield:

N-(4-(aminomethyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide + bis(2-chloroethyl)methylamine hydrochloride → Ponatinib Hydrochloride (1232836-25-7)

Guidance literature:

N-(4-(aminomethyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide; bis(2-chloroethyl)methylamine hydrochloride; With potassium carbonate; sodium iodide; In diethylene glycol dimethyl ether; at 170 ℃; for 8h;

With hydrogenchloride; In acetone;

upstream raw materials:

ponatinib

3-bromo-imidazo[1,2-b]pyridazine

methyl 3-iodo-4-methylbenzoate

methyl iodide

Downstream raw materials:

3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide

Refernces

• 1、 -. "A new crystalline form of acetylenic aryl compound". Paragraph 0056-0058. . Retrieved 2017/06/02.
• 2、 -. "MODIFICATIONS OF 3-(2-IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-[4-[(4-METHYL-1-PIPERAZINYL)METHYL]-3-(TRIFLUOROMETHYL)PHENYL] BENZAMIDE HYDROCHLORIDE SALT". Page/Page column 20. . Retrieved 2015/06/25.