2-Aminovaleric acid

Base Information

• Chemical Name: 2-Aminovaleric acid
• CAS No.: 760-78-1
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.148
• Hs Code.: 29224995
• Mol file: 760-78-1.mol

Synonyms:2-Aminovaleric acid;alpha-DL-Aminopentanoic acid;2-AMINO-PENTANOIC ACID;2-aminovalerate;2-aminopentanoate;2-aminovalerianic acid;alpha-amino-N-valerate;alpha-amino-N-valeric acid

Chemical Property of 2-Aminovaleric acid

Chemical Property:

• Appearance/Colour: white to off-white crystals or crystalline powder
• Melting Point: ≥300 °C (dec.)
• Boiling Point: 222.9 °C at 760 mmHg
• Flash Point: 88.6 °C
• PSA: 63.32000
• Density: 1.067 g/cm³
• LogP: 0.89870
• Water Solubility.: 1 g/10 mL (18℃)
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 117.078978594
• Heavy Atom Count: 8
• Complexity: 77

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Safety Statements: S24/25:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCC(C(=O)[O-])[NH3+]

Technology Process of 2-Aminovaleric acid

There total 27 articles about 2-Aminovaleric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxopentanoic acid (1821-02-9) → 2-aminopentanoic acid (760-78-1,498-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Zn(OAc)2, NaOH / methanol / 30 °C

2: H₂O

With sodium hydroxide; zinc diacetate; water; In methanol;

DOI:10.1021/ja00344a069

Reference yield:

hypotaurine (300-84-5) + 2-oxopentanoic acid (1821-02-9) → 2-aminopentanoic acid (760-78-1,498-18-0) + acetaldehyde (75-07-0,9002-91-9)

Guidance literature:

With 5,5'-dithiobis-(2-nitrobenzoic acid); pyridoxal 5'-phosphate; ω-amino acidpyruvate-transaminase from Caulobacter crescentus (UniProt ID Q9A3Q9); In aq. phosphate buffer; ethanol; at 30 ℃; pH=7.5; Reagent/catalyst; Solvent; Enzymatic reaction;

DOI:10.1039/d0cy02070b

Reference yield:

2-acetylamino-2-cyano-valeric acid ethyl ester (56548-09-5) → 2-aminopentanoic acid (760-78-1,498-18-0)

Guidance literature:

With hydrogen bromide;

upstream raw materials:

2-acetylamino-2-cyano-valeric acid ethyl ester

1-methyl-4-nitrosobenzene

hydrogen cyanide

1-(-)-2-amino-1-butanol

Downstream raw materials:

methyl (3R)-aminopentanoate

N-phthalyl-(RS)-norvaline

ethyl 2-aminopentanoate

N-acetylnorvaline

Refernces

• 1、 Gourbeyre, Léa,Heuson, Egon,Charmantray, Franck,Hélaine, Virgil,Debard, Adrien,Petit, Jean-Louis,de Berardinis, Véronique,Gefflaut, Thierry. "Biocatalysed synthesis of chiral amines: continuous colorimetric assays for mining amine-transaminases". . p. 904 - 911. Retrieved 2021/02/26.
• 2、 Park, Eul-Soo,Dong, Joo-Young,Shin, Jong-Shik. "Biocatalytic asymmetric synthesis of unnatural amino acids through the cascade transfer of amino groups from primary amines onto keto acids". . p. 3538 - 3542. Retrieved 2014/01/06.