(1S,4S,7S,8S,11S,12R,13S)-2,12-Dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.18,11.04,12]tridecan-9-one

Base Information Edit

Chemical Name:(1S,4S,7S,8S,11S,12R,13S)-2,12-Dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.18,11.04,12]tridecan-9-one
CAS No.:2115-91-5
Molecular Formula:C₁₆H₂₅NO₂
Molecular Weight:263.38
Hs Code.:29399990
DSSTox Substance ID:DTXSID70896917
Wikipedia:Dendrobine
Wikidata:Q76149937
Mol file:2115-91-5.mol

Synonyms:dendrobine;dendrobine hydrochloride

Suppliers and Price of (1S,4S,7S,8S,11S,12R,13S)-2,12-Dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.18,11.04,12]tridecan-9-one

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Dendrobine
10mg
$ 150.00

Medical Isotopes, Inc.
Dendrobine
100 mg
$ 2200.00

JR MediChem
Dendrobine 98%
20mg
$ 1400.00

DC Chemicals
Dendrobine >98%,StandardReferencesGrade
20 mg
$ 280.00

ChemScene
Dendrobine ≥98.0%
5mg
$ 178.00

ChemScene
Dendrobine ≥98.0%
10mg
$ 303.00

ChemScene
Dendrobine ≥98.0%
20mg
$ 514.00

Cayman Chemical
Dendrobine
50mg
$ 595.00

Cayman Chemical
Dendrobine
25mg
$ 340.00

Cayman Chemical
Dendrobine
10mg
$ 153.00

Total 102 raw suppliers

Chemical Property of (1S,4S,7S,8S,11S,12R,13S)-2,12-Dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.18,11.04,12]tridecan-9-one Edit

Chemical Property:

Vapor Pressure:8.25E-06mmHg at 25°C
Melting Point:135-136℃
Refractive Index:1.525
Boiling Point:374.602 °C at 760 mmHg
PKA:9.49±0.60(Predicted)
Flash Point:132.762 °C
PSA：29.54000
Density:1.101 g/cm³
LogP:2.09820
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:263.188529040
Heavy Atom Count:19
Complexity:435

Purity/Quality:

99% ^*data from raw suppliers

Dendrobine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1C2C3CCC4C3(C(C1OC2=O)N(C4)C)C
Isomeric SMILES:CC(C)[C@H]1[C@@H]2[C@@H]3CC[C@H]4[C@@]3([C@@H]([C@H]1OC2=O)N(C4)C)C
Description Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 μg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 μg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 μg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.
Uses Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord.

Technology Process of (1S,4S,7S,8S,11S,12R,13S)-2,12-Dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.18,11.04,12]tridecan-9-one

There total 101 articles about (1S,4S,7S,8S,11S,12R,13S)-2,12-Dimethyl-13-propan-2-yl-10-oxa-2-azatetracyclo[5.4.1.18,11.04,12]tridecan-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%