1H-1,7-NAPHTHYRIDIN-4-ONE

Base Information

• Chemical Name: 1H-1,7-NAPHTHYRIDIN-4-ONE
• CAS No.: 60122-51-2
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• Mol file: 60122-51-2.mol

Synonyms:1,7-Naphthyridin-4(1H)-one;

Chemical Property of 1H-1,7-NAPHTHYRIDIN-4-ONE

Chemical Property:

• Boiling Point: 295.3±40.0 °C(Predicted)
• PKA: 2.73±0.20(Predicted)
• PSA: 45.75000
• Density: 1.267±0.06 g/cm3(Predicted)
• LogP: 0.92310
• Storage Temp.: 2-8°C

Purity/Quality:

98% purity ^*data from raw suppliers

1,7-Naphthyridin-4(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,7-Naphthyridin-4(1H)-one is used in the preparation of naphthyridine derivatives for treatment of cell proliferative disorder.

Technology Process of 1H-1,7-NAPHTHYRIDIN-4-ONE

There total 8 articles about 1H-1,7-NAPHTHYRIDIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

8-chloro-1H-1,7-naphthyridin-4-one (1018812-91-3) → 1,7-naphthyridin-4(1H)-one (60122-51-2)

Guidance literature:

With hydrogen; sodium acetate; palladium on activated charcoal; In ethanol; water; at 30 ℃; for 0.5h;

DOI:10.1016/j.tet.2008.01.055

Reference yield:

C10H11N3O3 → 1,7-naphthyridin-4(1H)-one (60122-51-2)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 85 ℃;

Reference yield:

4-hydroxy-7-oxido-1,7-naphthyridine (1018812-88-8,952059-57-3) → 1,7-naphthyridin-4(1H)-one (60122-51-2)

Guidance literature:

With polymethylhydrosiloxane; palladium 10% on activated carbon; In ethanol; for 48h; Heating / reflux;

upstream raw materials:

4-hydroxy-7-oxido-1,7-naphthyridine

2,2-dimethyl-5-[[(1-oxidopyridin-3-yl)amino]methylidene]-1,3-dioxane-4,6-dione

8-chloro-1H-1,7-naphthyridin-4-one

methyl (4-pyridyl) ketone

Downstream raw materials:

4-chloro-[1,7]naphthyridine

2-[2-methoxy-4-(1,7-naphthyridin-4-yloxy)phenyl]acetic acid

1,7-naphthyridine-4-carboxylic acid

4-bromo-1,7-naphthyridine

Refernces

• 1、 -. "ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG". . . Retrieved 2015/06/03.
• 2、 -. "NAPHTHYRIDINE DERIVATIVES". Page/Page column 137. . Retrieved 2010/11/28.