AZD 1080

Base Information Edit

Chemical Name:AZD 1080
CAS No.:612487-72-6
Molecular Formula:C19H18N4O2
Molecular Weight:334.37
Hs Code.:
Mol file:612487-72-6.mol

Synonyms:2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile;1H-INDOLE-5-CARBONITRILE,2-HYDROXY-3-[5-(4-MORPHOLINYLMETHYL)-2-PYRIDINYL];Kinome_2945;

Suppliers and Price of AZD 1080

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AZD1080
10mg
$ 360.00

DC Chemicals
AZD1080 >98%
100 mg
$ 600.00

DC Chemicals
AZD1080 >98%
1 g
$ 1900.00

DC Chemicals
AZD1080 >98%
250 mg
$ 1000.00

Crysdot
AZD1080 98+%
100mg
$ 900.00

Crysdot
AZD1080 98+%
25mg
$ 320.00

Crysdot
AZD1080 98+%
10mg
$ 260.00

Crysdot
AZD1080 98+%
5mg
$ 168.00

ChemScene
AZD1080 99.46%
10mg
$ 150.00

ChemScene
AZD1080 99.46%
5mg
$ 90.00

Total 35 raw suppliers

Chemical Property of AZD 1080 Edit

Chemical Property:

Boiling Point:594.0±50.0 °C(Predicted)
PKA:8.32±0.50(Predicted)
PSA：85.17000
Density:1.40±0.1 g/cm3(Predicted)
LogP:2.57728
Solubility.:insoluble in H2O; insoluble in EtOH; ≥16.7 mg/mL in DMSO

Purity/Quality:

98%,99%, ^*data from raw suppliers

AZD1080 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description The two isoforms of glycogen synthase kinase 3, GSK3α and GSK3β, constitutively phosphorylate and inactivate glycogen synthase, preventing glycogen synthesis. They also phosphorylate proteins that are relevant to Alzheimer’s disease and osteogenesis. AZD 1080 is a potent, brain permeable inhibitor of GSK3α and GSK3β (Kis = 6.9 and 31 nM, respectively). It shows >14-fold selectivity against several kinases, receptors, enzymes, and ion channels. AZD 1080 inhibits tau phosphorylation in cells. It shows good bioavailability after oral administration in vivo, inhibiting hippocampal tau phosphorylation and reversing cognitive deficits induced by the NMDA receptor antagonist (+)-MK-801 . In humans, oral AZD 1080 inhibits GSK3 activity in peripheral blood lymphocytes following an initial delay in response.
Uses AZD1080 is a selective, orally active, brain permeable glycogen synthase kinase-3 (GSK3) inhibitor (1,2). AZD1080 has shown to rescue synaptic plasticity deficits in rodent brain and exhibit peripheral target engagement in humans.

Technology Process of AZD 1080

There total 6 articles about AZD 1080 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1073614-10-4
1,2-dihydroxy-3-(5-morpholin-4-ylmethyl-pyridin-2-yl)-1H-indole-5-carbonitrile

: 612487-72-6
AZD1080

Guidance literature:: 1,2-dihydroxy-3-(5-morpholin-4-ylmethyl-pyridin-2-yl)-1H-indole-5-carbonitrile; With iron; acetic acid; at 60 ℃; for 3h;

With ammonia; In methanol; dichloromethane; Product distribution / selectivity;

Reference yield: 73.0%

: 612488-09-2
5-bromo-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indol-2-ol

: 557-21-1
dicyanozinc

: 612487-72-6
AZD1080

Guidance literature:: 5-bromo-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indol-2-ol; With zinc; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 50 ℃; for 0.0666667h;

dicyanozinc; In N,N-dimethyl-formamide; at 50 ℃; for 3h; Product distribution / selectivity;