(2R)-2-cyclohexyl-Pyrrolidine

Base Information

• Chemical Name: (2R)-2-cyclohexyl-Pyrrolidine
• CAS No.: 1232403-88-1
• Molecular Formula: C10H19N
• Molecular Weight: 153.268
• Mol file: 1232403-88-1.mol

Synonyms:(2R)-2-cyclohexyl-Pyrrolidine

Chemical Property of (2R)-2-cyclohexyl-Pyrrolidine

Chemical Property:

• PSA: 12.03000
• LogP: 2.64750

Purity/Quality:

(2R)-2-cyclohexyl-Pyrrolidine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-cyclohexyl-Pyrrolidine

There total 6 articles about (2R)-2-cyclohexyl-Pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyclohexyl-1-pyrroline (152711-33-6) → C10H19N (1232403-88-1) + C10H19N (1232406-43-7)

Guidance literature:

With (2S,3R)-2-amino-3-hydroxybutanamide; streptavidin biotin-wild type; C₄₂H₆₄Cl₄Ir₂N₆O₄S₂; In dimethyl sulfoxide; at 30 - 50 ℃; for 18h; pH=7.8; Reagent/catalyst; Overall yield = 98 %; enantioselective reaction;

DOI:10.1002/cctc.201300825

Reference yield:

2-cyclohexyl-1-pyrroline (152711-33-6) → C10H19N (1232403-88-1)

Guidance literature:

With Cp*Ir(biot-p-L)Cl; monoamine oxidase from Aspergillus niger-9; streptavidin S₁₁₂A mutant; oxygen; sodium formate; catalase from bovine liver; In aq. buffer; at 37 ℃; pH=7.8; enantioselective reaction; Enzymatic reaction;

DOI:10.1038/nchem.1498

Reference yield:

2-cyclohexylpyrrolidine (367281-02-5) → C10H19N (1232403-88-1)

Guidance literature:

With Cp*Ir(biot-p-L)Cl; monoamine oxidase from Aspergillus niger-9; streptavidin S₁₁₂A-K₁₂₃₁N mutant; oxygen; sodium formate; catalase from bovine liver; In aq. buffer; at 37 ℃; pH=7.8; enantioselective reaction; Enzymatic reaction;

DOI:10.1038/nchem.1498

upstream raw materials:

Cyclohexyl iodide

tert-butyl (R)-2-cyclohexylpyrrolidine-1-carboxylate

1-bromocyclohexane

2-cyclohexyl-1-pyrroline

Refernces

• 1、 Hussain, Shahed,Leipold, Friedemann,Man, Henry,Wells, Elizabeth,France, Scott P.,Mulholland, Keith R.,Grogan, Gideon,Turner, Nicholas J.. "An (R)-imine reductase biocatalyst for the asymmetric reduction of cyclic imines". . p. 579 - 583. Retrieved 2015/03/05.
• 2、 Cordier, Christopher J.,Lundgren, Rylan J.,Fu, Gregory C.. "Enantioconvergent cross-couplings of racemic alkylmetal reagents with unactivated secondary alkyl electrophiles: Catalytic asymmetric Negishi α-alkylations of N-Boc-pyrrolidine". . p. 10946 - 10949. Retrieved 2013/08/23.