Geclosporin

Base Information

• Chemical Name: Geclosporin
• CAS No.: 74436-00-3
• Molecular Formula: C₆₃H₁₁₃N₁₁O₁₂
• Molecular Weight: 1216.66
• UNII: UA3JNW70T9
• Nikkaji Number: J413.947J
• Wikidata: Q27290967
• NCI Thesaurus Code: C170024
• ChEMBL ID: CHEMBL2107422
• Mol file: 74436-00-3.mol

Synonyms:2-norVal-cyclosporin;2-norvalyl-cyclosporin;7-L-norvaline-cyclosporin A;cyclosporin G;cyclosporin, 2-norvaline-;cyclosporin, norVal(2)-;cyclosporine G;norvaline(2)-cyclosporine;NVa(2)-cyclosporin;OG 37-325;OG37-325

Chemical Property of Geclosporin

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 196-197°
• Boiling Point: 1297.8°C at 760 mmHg
• PKA: 13.32±0.70(Predicted)
• Flash Point: 738.7°C
• PSA: 278.80000
• Density: 1.013g/cm³
• LogP: 4.53960
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 7.9
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 16
• Exact Mass: 1215.85701808
• Heavy Atom Count: 86
• Complexity: 2340

Purity/Quality:

≥ 97% ^*data from raw suppliers

CyclosporinG ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
• Isomeric SMILES: CCC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
• Uses: Cylclosporin G is a derivative of Cyclosporin A, an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity. Cylclosporin G is a derivative of Cyclosporin A (C989900), an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.