AKOS BC-0227

Base Information

• Chemical Name: AKOS BC-0227
• CAS No.: 91640-63-0
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol file: 91640-63-0.mol

Synonyms:ASISCHEM D50963;AKOS BC-0227;1-(4-AMINOPHENYL)-CYCLOPENTANECARBOXYLIC ACID

Chemical Property of AKOS BC-0227

Chemical Property:

• PSA: 63.32000
• LogP: 2.74640

Purity/Quality:

≥95% ^*data from raw suppliers

1-(4-Amino-phenyl)-cyclopentanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS BC-0227

There total 5 articles about AKOS BC-0227 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-aminophenyl)cyclopentane-1-carbonitrile (115279-73-7) → 1-(p-aminophenyl)cyclopentanecarboxylic acid (91640-63-0)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 105 ℃; for 9h; Microwave irradition;

Reference yield: 91.6%

→ 1-(4-methoxyacetylaminophenyl)cyclopentanecarboxylic acid (371918-64-8) + 1-(p-aminophenyl)cyclopentanecarboxylic acid (91640-63-0)

Guidance literature:

Reference yield: 76.0%

1-(4-nitro-phenyl)-cyclopentanecarboxylic acid (52648-77-8) → 1-(p-aminophenyl)cyclopentanecarboxylic acid (91640-63-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 24h; under 760 Torr; Ambient temperature;

DOI:10.1002/(SICI)1099-1344(199605)38:5<471::AID-JLCR854>3.0.CO;2-Q

upstream raw materials:

1-(4-nitro-phenyl)-cyclopentanecarboxylic acid

1-phenyl-1-cyclopentanecarboxylic acid

1-(4-aminophenyl)cyclopentane-1-carbonitrile

Downstream raw materials:

1-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-cyclopentanecarboxylic acid

3,4-dimethoxy-N-[4-(1-methylcarbamoyl-cyclopentyl)-phenyl]-benzamide

1-[4-(3,4-dimethoxy-benzoylamino)-phenyl]-cyclopentanecarboxylic acid methyl ester

2-(diethylamino)ethyl 1-(p-cyanophenyl)cyclopentanecarboxylate

Refernces

• 1、 -. "13-substituted milbemycin derivatives, their preparation and their use against insects and other pests". . . Retrieved 2008/06/13.