Clopidogrel impurity C

Base Information Edit

Chemical Name:Clopidogrel impurity C
CAS No.:120202-69-9
Molecular Formula:C16H16ClNO2S
Molecular Weight:321.828
Hs Code.:
UNII:295YY352H3
DSSTox Substance ID:DTXSID801317036
Nikkaji Number:J1.485.220D
ChEMBL ID:CHEMBL1317678
Mol file:120202-69-9.mol

Synonyms:Clopidogrel impurity C;120202-69-9;r-clopidogrel;(-)-Clopidogrel;Clopidogrel, (R)-;(R)-(-)-Clopidogrel;295YY352H3;SR-25989;methyl (2R)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate;(R)-(-)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno(3,2-C)pyrid-5-yl)acetate;Methyl (R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate;(r)-clopidogrel;SCHEMBL1031641;CHEMBL1317678;UNII-295YY352H3;DTXSID801317036;AKOS026751461;Clopidogrel Related Compound C [USP];(R)-methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate;NCGC00163329-01;A25010;EN300-18565832;CLOPIDOGREL BESILATE IMPURITY C [EP IMPURITY];methyl (2r)-(2-chlorophenyl)(6,7-di-hydro thieno[3,2-c]pyridin-5(4h )-yl]acetate;methyl (2R)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate;(alphaR)-alpha-(2-Chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-acetic acid methyl ester;methyl (2s)-2-(2-chlorophenyl)-2-(9-thia-4-azabicyclo[4.3.0]nona-7,10-dien-4-yl)acetate;ClopidogrelHydrobromide;ClopidogrelHydrogenSulfateBase;ClopidogrelHcl;Methyl (+)-(S)-alpha-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate;(S)- alpha-(2-Chloro;THIENO(3,2-C)PYRIDINE-5(4H)-ACETIC ACID, .ALPHA.-(2-CHLOROPHENYL)-6,7-DIHYDRO-, METHYL ESTER, (.ALPHA.R)-;Thieno(3,2-C)pyridine-5(4H)-acetic acid, alpha-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (alphaR)-

Suppliers and Price of Clopidogrel impurity C

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 6 raw suppliers

Chemical Property of Clopidogrel impurity C Edit

Chemical Property:

PSA：57.78000
LogP:3.61180
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:321.0590276
Heavy Atom Count:21
Complexity:381

Purity/Quality:: >=98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Isomeric SMILES:COC(=O)[C@@H](C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3

Technology Process of Clopidogrel impurity C

There total 10 articles about Clopidogrel impurity C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 929200-24-8
sodium (R)-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-acetate

: 77-78-1
dimethyl sulfate

: 120202-69-9,94188-84-8
methyl (R)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate

Guidance literature:: With PEG₄₀₀; sodium hydrogencarbonate; In water; butan-1-ol; at 10 - 40 ℃; for 31h; pH=~ 10;

Reference yield:

: clopidogrel (1R)-(-)-camphor-10-sulfonate

: 847986-65-6
(R)-(-)-camphorsulphonic scid salt of methyl (R)-(-)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate

: 113665-84-2,94188-84-8
(S)-(+)-clopidogrel

: 120202-69-9,94188-84-8
methyl (R)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 67-56-1
methanol

: (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

: 113665-84-2,94188-84-8
(S)-(+)-clopidogrel

: 120202-69-9,94188-84-8
methyl (R)-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)acetate

Guidance literature:: methanol; (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide; With sulfuric acid; for 60h; Heating / reflux;

With water; sodium hydrogencarbonate; In methanol; Product distribution / selectivity;