4-BroMo-1,3-dihydroisobenzofuran

Base Information

• Chemical Name: 4-BroMo-1,3-dihydroisobenzofuran
• CAS No.: 1402667-16-6
• Molecular Formula: C₈H₇BrO
• Molecular Weight: 199.047
• Hs Code.: 2932990090
• Mol file: 1402667-16-6.mol

Synonyms:4-BroMo-1,3-dihydroisobenzofuran;4-Bromo-1,3-dihydro-2-benzofuran

Chemical Property of 4-BroMo-1,3-dihydroisobenzofuran

Chemical Property:

• Boiling Point: 269.9±40.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.582±0.06 g/cm3(Predicted)
• LogP: 2.47930
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-1,3-dihydro-2-benzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-1,3-dihydroisobenzofuran

There total 2 articles about 4-BroMo-1,3-dihydroisobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-1,2-bis(bromomethyl)benzene (127168-82-5) → 4-bromo-1,3-dihydroisobenzofuran (1402667-16-6)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In 1,4-dioxane;

DOI:10.1016/j.tetlet.2007.03.069

Reference yield:

2,3-dimethylbromobenzene (576-23-8) → 4-bromo-1,3-dihydroisobenzofuran (1402667-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-bromosuccinimide; AIBN

2: tetrabutylammonium hydroxide / dioxane

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetra(n-butyl)ammonium hydroxide; In 1,4-dioxane;

DOI:10.1016/j.tetlet.2007.03.069

Reference yield:

4-bromo-1,3-dihydroisobenzofuran (1402667-16-6) → 1,3-dihydro-4-isobenzo- furanol (417704-22-4)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium hydroxide; tert-butyl XPhos; In 1,4-dioxane; water; at 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

upstream raw materials:

3-bromo-1,2-bis(bromomethyl)benzene

2,3-dimethylbromobenzene

Downstream raw materials:

1,3-dihydro-4-phenylisobenzofuran

1,3-dihydro-4-isobenzo- furanol

Refernces

• 1、 Foubelo, Francisco,García, Daniel,Moreno, Benjamín,Yus, Miguel. "Regiochemistry in the reductive opening of phthalan derivatives". . p. 3379 - 3383. Retrieved 2008/02/12.