N-methylpyrrolidone

Base Information

• Chemical Name: N-methylpyrrolidone
• CAS No.: 26138-58-9
• Molecular Formula: C₅H₉NO
• Molecular Weight: 99.1326
• Mol file: 26138-58-9.mol

Synonyms:

Chemical Property of N-methylpyrrolidone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methylpyrrolidone

There total 101 articles about N-methylpyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(dimethylchlorosilylmethyl)-2-pyrrolidone (76128-61-5) → 1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + diisopropoxydimethylsilane (5575-49-5)

Guidance literature:

With sodium isopropylate; In isopropyl alcohol; at 60 ℃; for 3h;

Reference yield: 88.0%

4-butanolide (96-48-0) + dimethyl amine (124-40-3) → 1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + methanol (67-56-1)

Guidance literature:

With water; ZSM-5; at 280 ℃;

Reference yield: 40.8%

4-butanolide (96-48-0) + dimethyl amine (124-40-3) + methylamine (74-89-5) → 1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + γ-hydroxybutyric acid monomethylamide (37941-69-8) + N,N-dimethyl-γ-hydroxybutyramide (18190-25-5)

Guidance literature:

at 270 ℃; for 0.166667h;

upstream raw materials:

diazomethane

pyridin-4-ol

diethyl ether

2-pyrrolidinon

Downstream raw materials:

4-Methoxy-N-[1-methyl-pyrrolidin-(2E)-ylidene]-thiobenzamide

(3RS,1'RS)-1-methyl-3-(1'-methyl-3'-phenyl-3'-((trimethylsilyl)oxy)-2'-propenyl)-2-pyrrolidinone

1-methyl-3-(trimethylsilyl)-2-pyrrolidinone

1-methyl-3-nicotinoyl-2-pyrrolidone

Refernces

• 1、 Bassindale, Alan R.,Stout, Tim. "THE INTERACTION OF ELECTROPHILIC SILANES (Me3SiX, X= ClO4, I, CF3SO3, Br, Cl) WITH NUCLEOPHILES. THE NATURE OF SILYLATION MIXTURES IN SOLUTION.". . p. 3403 - 3406. Retrieved 1985.
• 2、 -. "Preparation of alkylated compounds using the trialkylphosphate". Paragraph 0184-0185; 0210. . Retrieved 2021/11/02.
• 3、 Fuse, Shinichiro,Komuro, Keiji,Otake, Yuma,Masui, Hisashi,Nakamura, Hiroyuki. "Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Microflow Reactor". supporting information. p. 7525 - 7532. Retrieved 2021/03/17.