3-Methyl-1H-pyrrole-2,5-dicarbaldehyde

Base Information

• Chemical Name: 3-Methyl-1H-pyrrole-2,5-dicarbaldehyde
• CAS No.: 90935-74-3
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.138
• Mol file: 90935-74-3.mol

Synonyms:3-Methyl-1H-pyrrole-2,5-dicarbaldehyde

Chemical Property of 3-Methyl-1H-pyrrole-2,5-dicarbaldehyde

Chemical Property:

• Melting Point: 79-80 °C(Solv: hexane (110-54-3))
• Boiling Point: 294.6±40.0 °C(Predicted)
• PKA: 13.70±0.50(Predicted)
• PSA: 49.93000
• Density: 1.277±0.06 g/cm3(Predicted)
• LogP: 0.94810

Purity/Quality:

95+% ^*data from raw suppliers

3-Methyl-1H-pyrrole-2,5-dicarbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methyl-1H-pyrrole-2,5-dicarbaldehyde

There total 15 articles about 3-Methyl-1H-pyrrole-2,5-dicarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,5-Bis-benzo[1,3]dithiol-2-yl-3-methyl-1H-pyrrole → 5-formyl-4-methyl-1H-pyrrole-2-carbaldehyde (90935-74-3)

Guidance literature:

With tetrafluoroboric acid; mercury(II) oxide; In dimethyl sulfoxide; 1.) 0-5 deg C, 30 min, 2.) 60 deg C, 2 h;

DOI:10.1039/p19960002365

Reference yield: 39.0%

5-(2-Cyano-2-ethoxycarbonylvinyl)-4-methylpyrrole-2-carbaldehyde (178941-14-5) → 5-formyl-4-methyl-1H-pyrrole-2-carbaldehyde (90935-74-3)

Guidance literature:

With potassium hydroxide; In methanol; for 0.666667h; Heating;

DOI:10.1039/P19960001235

Reference yield: 35.0%

4-methyl-6H-pyrrolo[1,2-c][1,2,3]triazole (64804-02-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-formyl-4-methyl-1H-pyrrole-2-carbaldehyde (90935-74-3)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 14h; further reaction of the corresponding 4,5-dimethylderivative;

DOI:10.1021/jo00289a034

upstream raw materials:

3-methylpyrrole

benzoimidazole

5,10-Bis-dimethylamino-2,7-dimethyl-5H,10H-dipyrrolo[1,2-a;1',2'-d]pyrazine-3,8-dicarbaldehyde

4-methyl-6H-pyrrolo[1,2-c][1,2,3]triazole

Downstream raw materials:

all-trans-11,14-imino-retinal

Refernces

• 1、 Boudif, Arezki,Momenteau, Michel. "A new convergent method for porphyrin synthesis based on a '3 + 1' condensation". . p. 1235 - 1242. Retrieved 2007/10/03.
• 2、 Dulcere, Jean-Pierre,Tawil, Mohamed,Santelli, Maurice. "Synthesis of 6H-Pyrrolotriazoles and 5H-Pyrrolotetrazoles: Alkylation and Acylation of the Monoanions". . p. 571 - 575. Retrieved 2007/10/02.