Methyl-(2-Methyl-6-nitro-phenyl)-aMine

Base Information

• Chemical Name: Methyl-(2-Methyl-6-nitro-phenyl)-aMine
• CAS No.: 70254-74-9
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Mol file: 70254-74-9.mol

Synonyms:Methyl-(2-Methyl-6-nitro-phenyl)-aMine

Chemical Property of Methyl-(2-Methyl-6-nitro-phenyl)-aMine

Chemical Property:

• PSA: 57.85000
• LogP: 2.54110

Purity/Quality:

98% ^*data from raw suppliers

N,2-Dimethyl-6-nitroaniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl-(2-Methyl-6-nitro-phenyl)-aMine

There total 12 articles about Methyl-(2-Methyl-6-nitro-phenyl)-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-methyl-6-nitrotrifluoroacetanilide (2145-35-9) + dimethyl sulfate (77-78-1) → 2,N-dimethyl-6-nitro-aniline (70254-74-9)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In toluene; Ambient temperature;

DOI:10.1080/00397919608003827

Reference yield: 63.0%

2-Methyl-6-nitroaniline (570-24-1) + methyl iodide (74-88-4) → 2,N-dimethyl-6-nitro-aniline (70254-74-9) + 4-methyl-1-methoxybenzimidazole (161958-71-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 12h; Heating;

DOI:10.1016/0040-4020(95)00127-T

Reference yield: 42.1%

Dimethyl oxalate (553-90-2) + 2-Methyl-6-nitroaniline (570-24-1) → 2,N-dimethyl-6-nitro-aniline (70254-74-9)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; Heating / reflux;

upstream raw materials:

N-methyl-N-nitro-o-toluidine

N,2-dimethylaniline

2-methyl-6-nitroanisole

methylamine

Downstream raw materials:

C₉H₁₁N₃

N₁,6-dimethylbenzene-1,2-diamine

1,7-dimethyl-1H-benzo[d]imidazole

Refernces

• 1、 Windisch, Marc Peter,Jo, Suyeon,Kim, Hee-Young,Kim, Soo-Hyun,Kim, Keumhyun,Kong, Sunju,Jeong, Hyangsuk,Ahn, Sujin,No, Zaesung,Hwang, Jong Yeon. "Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action". . p. 35 - 42. Retrieved 2014/04/17.
• 2、 Hayes, Martin E.,Wallace, Grier A.,Grongsaard, Pintipa,Bischoff, Agnieszka,George, Dawn M.,Miao, Wenyan,McPherson, Michael J.,Stoffel, Robert H.,Green, David W.,Roth, Gregory P.. "Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3". . p. 1573 - 1576. Retrieved 2008/09/21.