Arachidonoyl-N-methyl amide

Base Information

• Chemical Name: Arachidonoyl-N-methyl amide
• CAS No.: 156910-29-1
• Molecular Formula: C₂₁H₃₅NO
• Molecular Weight: 317.515
• Mol file: 156910-29-1.mol

Synonyms:Arachidonoyl-N-methyl amide

Chemical Property of Arachidonoyl-N-methyl amide

Chemical Property:

• Boiling Point: 469.6±34.0 °C(Predicted)
• PKA: 16.43±0.46(Predicted)
• PSA: 29.10000
• Density: 0.892±0.06 g/cm3(Predicted)
• LogP: 6.26900

Purity/Quality:

99% ^*data from raw suppliers

Arachidonoyl-N-methylAmide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Arachidonoyl-N-methyl amide is a cell-cell communication inhibitor.

Technology Process of Arachidonoyl-N-methyl amide

There total 3 articles about Arachidonoyl-N-methyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

→ N-methylarachidonamide (156910-29-1)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

In dichloromethane;

Reference yield:

all cis 5,8,11,14-eicosatetraenoic acid (506-32-1,236743-58-1) → N-methylarachidonamide (156910-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2, DMF / CH₂Cl₂ / 25 °C

2: CH₂Cl₂ / 25 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/S0960-894X(99)00148-1

Reference yield:

arachidonoyl chloride (57303-04-5) + methylamine (74-89-5) → N-methylarachidonamide (156910-29-1)

Guidance literature:

In dichloromethane; water; for 0.25h; Yield given;

DOI:10.1021/jm960752x

upstream raw materials:

arachidonoyl chloride

methylamine

all cis 5,8,11,14-eicosatetraenoic acid

Refernces

• 1、 -. "A METHOD OF TREATING PERIPHERAL INFLAMMATORY DISEASE". Paragraph 0078-0084; 0113-0114. . Retrieved 2016/12/01.