Ebselen Oxide

Base Information

• Chemical Name: Ebselen Oxide
• CAS No.: 104473-83-8
• Molecular Formula: C13H9NO2Se
• Molecular Weight: 290.18
• Mol file: 104473-83-8.mol

Synonyms:Ebselen Oxide;1-Oxide-2-phenyl-1,2-benzisoselenazol-3(2H)-one;Ebselen selenoxide;NSC 639772

Chemical Property of Ebselen Oxide

Chemical Property:

• Boiling Point: 277.3±23.0 °C(Predicted)
• PSA: 37.38000
• LogP: 1.53770
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble5mg/mL (clear solution)

Purity/Quality:

97% ^*data from raw suppliers

Ebselen Oxide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 23/25-33-50/53
• Safety Statements: 20/21-28-45-60-61

MSDS Files:

SDS file from LookChem

Useful:

• Description: Ebselen is an excellent scavenger of peroxynitrite and is used for the treatment of cerebral infarctions. Ebselen oxide, formed by the oxidation of ebselen, lacks antioxidant activity, indicating that it can serve as a negative control for ebselen.
• Uses: Ebselen Oxide is an excellent scavenger of peroxynitrite.

Technology Process of Ebselen Oxide

There total 4 articles about Ebselen Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,2‘-diselenobis(N-phenylbenzamide) (106663-84-7) → 2-phenyl-1,2-benzioselenazol-3(2H)-one selenoxide (104473-83-8)

Guidance literature:

With dihydrogen peroxide; In acetonitrile; for 8h; Ambient temperature;

Reference yield: 70.0%

2-phenyl-1,2-benzoisoselenazol-3(2H)-one (60940-34-3) → 2-phenyl-1,2-benzioselenazol-3(2H)-one selenoxide (104473-83-8)

Guidance literature:

With dihydrogen peroxide; In dichloromethane; Mechanism; Ambient temperature; var. hydroperoxides;

Reference yield: 19.0%

2-phenyl-1,2-benzoisoselenazol-3(2H)-one (60940-34-3) → 2-methylseleno-N-phenylbenzamide (60940-24-1) + 2-phenyl-1,2-benzioselenazol-3(2H)-one selenoxide (104473-83-8) + dibenzo<1,4>selenazepin-11(10H)-one (108085-74-1) + 2-(2-hydroxy-2-methylpropylseleno)benzanilide

Guidance literature:

In tert-butyl alcohol; for 10h; Mechanism; Irradiation;

DOI:10.1246/bcsj.59.2179

upstream raw materials:

2-phenyl-1,2-benzoisoselenazol-3(2H)-one

2,2‘-diselenobis(N-phenylbenzamide)

GLUTATHIONE

Downstream raw materials:

2-phenyl-1,2-benzoisoselenazol-3(2H)-one

ebselen seleninic acid

dibenzyl disulphide

S-(2-phenyl carbamoyl benzeneselenenyl)benzylmercaptan

Refernces

• 1、 Bhabak, Krishna P.,Vernekar, Amit A.,Jakka, Surendar R.,Roy, Gouriprasanna,Mugesh, Govindasamy. "Mechanistic investigations on the efficient catalytic decomposition of peroxynitrite by ebselen analogues". . p. 5193 - 5200. Retrieved 2011.
• 2、 Mlochowski, Jacek,Kloc, Krystian,Syper, Ludwik,Inglot, Anna D.,Piasecki, Egbert. "Aromatic and Azaaromatic Diselenides, Benzisoselenazolones and Related Compounds as Immunomodulators Active in Humans: Synthesis and Properties". . p. 1239 - 1244. Retrieved 2007/10/02.