3-Chloro-2-fluoro-4-iodopyridine

Base Information

• Chemical Name: 3-Chloro-2-fluoro-4-iodopyridine
• CAS No.: 796851-05-3
• Molecular Formula: C₅H₂ClFIN
• Molecular Weight: 257.433
• Mol file: 796851-05-3.mol

Synonyms:3-Chloro-2-fluoro-4-iodopyridine;2 - fluoro-3 - chloro-4 - Iodopyridine;Pyridine, 3-chloro-2-fluoro-4-iodo-

Chemical Property of 3-Chloro-2-fluoro-4-iodopyridine

Chemical Property:

• Melting Point: 98-99 °C
• Boiling Point: 254.8±35.0 °C(Predicted)
• PKA: -4.10±0.18(Predicted)
• PSA: 12.89000
• Density: 2.129±0.06 g/cm3(Predicted)
• LogP: 2.47870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%, ^*data from raw suppliers

3-Chloro-2-fluoro-4-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Chloro-2-fluoro-4-iodopyridine

There total 1 articles about 3-Chloro-2-fluoro-4-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-chloro-2-fluoropyridine (1480-64-4) → 3-chloro-2-fluoro-4-iodopyridine (796851-05-3)

Guidance literature:

3-chloro-2-fluoropyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere; Large scale;

With iodine; In tetrahydrofuran; for 0.5h; Inert atmosphere; Large scale;

Reference yield:

sodium methylate (124-41-4) + 3-chloro-2-fluoro-4-iodopyridine (796851-05-3) → 3-chloro-4-iodo-2-methoxypyridine (1227603-07-7)

Guidance literature:

In methanol; dimethyl sulfoxide; at 70 ℃; for 1h;

Reference yield:

3-chloro-2-fluoro-4-iodopyridine (796851-05-3) → 1,2-diamino-3-chloro-4-iodopyridin-1-ium 2,4,6-trimethylbenzenesulfonate

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / water; dimethyl sulfoxide / 3 h / 105 °C / Sealed tube

2: dichloromethane / 0 - 20 °C

With ammonia; In dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

3-chloro-2-fluoropyridine

Downstream raw materials:

3-chloro-4-iodo-2-methoxypyridine

Refernces

• 1、 -. "Aryl spiro compound containing formamidine as well as preparation method and application of aryl spiro compound". Paragraph 0061-0064. . Retrieved 2021/08/14.
• 2、 -. "PROCESS OF MANUFACTURE OF A COMPOUND FOR INHIBITING THE ACTIVITY OF SHP2". Paragraph 00308-00310; 00323; 00326. . Retrieved 2020/05/12.