5α-Pregnan-3-one

Base Information

• Chemical Name: 5α-Pregnan-3-one
• CAS No.: 14778-11-1
• Molecular Formula: C21H34O
• Molecular Weight: 302.5
• Mol file: 14778-11-1.mol

Synonyms:5α-Pregnan-3-one

Chemical Property of 5α-Pregnan-3-one

Chemical Property:

• PSA: 17.07000
• LogP: 5.62440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5α-Pregnan-3-one

There total 19 articles about 5α-Pregnan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5α-pregnan-3β-ol (4352-06-1) → 5alpha-pregnan-3-one (14778-11-1)

Guidance literature:

With chromium(VI) oxide; acetic acid;

DOI:10.1080/00221320209598673 DOI:10.1002/hlca.193902201165

Reference yield:

5α-pregna-1,20-dien-3-one (65754-62-3) → 5alpha-pregnan-3-one (14778-11-1)

Guidance literature:

With hydrogen; palladium on activated charcoal;

DOI:10.1016/0039-128X(77)90028-9

Reference yield:

5-pregnen-3β-ol (2862-58-0) → 5alpha-pregnan-3-one (14778-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / PtO₂ / acetic acid

2: CrO₃, AcOH / CHCl₃

With chromium(VI) oxide; hydrogen; acetic acid; platinum(IV) oxide; In chloroform; acetic acid;

DOI:10.1016/S0031-9422(00)94070-6

upstream raw materials:

5α-pregnan-3β-ol

pregna-1,4,20-trien-3-one

5α-pregna-1,20-dien-3-one

dimethyl-(5α-pregnan-3α-yl)-amine

Downstream raw materials:

5α-pregnane

Refernces

• 1、 Kohli,J.M. et al.. "-". . p. 442 - 445. Retrieved 1971.
• 2、 Iida, Takashi,Omura, Kaoru,Sakiyama, Ryou,Kodomari, Mitsuo. "Regioselective dehydrogenation of 3-keto-steroids to form conjugated enones using o-iodoxybenzoic acid and trifluoroacetic acid catalysis". . p. 45 - 51. Retrieved 2014/03/21.