(R)-1-Boc-2-(chloromethyl)pyrrolidine

Base Information

• Chemical Name: (R)-1-Boc-2-(chloromethyl)pyrrolidine
• CAS No.: 210963-90-9
• Molecular Formula: C10H18ClNO2
• Molecular Weight: 219.71
• DSSTox Substance ID: DTXSID80708370
• Wikidata: Q82642649
• Mol file: 210963-90-9.mol

Synonyms:210963-90-9;(R)-1-Boc-2-(chloromethyl)pyrrolidine;(R)-tert-Butyl 2-(chloromethyl)pyrrolidine-1-carboxylate;(R)-1-BOC-2-CHLOROMETHYL-PYRROLIDINE;tert-Butyl (2R)-2-(chloromethyl)pyrrolidine-1-carboxylate;1-t-butoxycarbonyl-(2R)-2-chloromethylpyrrolidine;SCHEMBL3898258;DTXSID80708370;KTDOGEILJSFSSG-MRVPVSSYSA-N;MFCD09701400;AKOS015999597;CS-0341706;A848014;1-t-butoxycarbonyl-(2R)-2-chloromethyl pyrrolidine;(R)-tert-Butyl2-(chloromethyl)pyrrolidine-1-carboxylate

Chemical Property of (R)-1-Boc-2-(chloromethyl)pyrrolidine

Chemical Property:

• PSA: 29.54000
• LogP: 2.56260
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 219.1026065
• Heavy Atom Count: 14
• Complexity: 213

Purity/Quality:

98% ^*data from raw suppliers

(R)-1-Boc-2-(chloromethyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCCC1CCl
• Isomeric SMILES: CC(C)(C)OC(=O)N1CCC[C@@H]1CCl

Technology Process of (R)-1-Boc-2-(chloromethyl)pyrrolidine

There total 2 articles about (R)-1-Boc-2-(chloromethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(tert-butoxycarbonyl)prolin-2R-ol (59378-81-3,69610-40-8,83435-58-9) → 1-t-butoxycarbonyl-(2R)-2-chloromethylpyrrolidine (210963-90-9,1142400-61-0,403735-05-7)

Guidance literature:

With tetrachloromethane; PS-triphenylphosphine; In dichloromethane; for 12h; Heating;

DOI:10.1016/S0040-4039(03)01117-1

Reference yield:

D-prolinol (68832-13-3) + di-tert-butyl dicarbonate (24424-99-5) → 1-t-butoxycarbonyl-(2R)-2-chloromethylpyrrolidine (210963-90-9,1142400-61-0,403735-05-7)

Guidance literature:

With triethylamine; lithium chloride; In N-methyl-acetamide; dichloromethane; ethyl acetate;

Reference yield:

m-cyanophenol (873-62-1) + 1-t-butoxycarbonyl-(2R)-2-chloromethylpyrrolidine (210963-90-9,1142400-61-0,403735-05-7) → 1-t-butoxycarbonyl-(2R)-2-[(3-cyanophenoxy)methyl]pyrrolidine

Guidance literature:

With potassium iodide; potassium carbonate; In dimethylamide; ethyl acetate;

upstream raw materials:

1-(tert-butoxycarbonyl)prolin-2R-ol

D-prolinol

di-tert-butyl dicarbonate

Refernces

• 1、 -. "BENZAMIDINE DERIVATIVES". . . Retrieved 2008/06/13.