5-bromo-3-phenyl Salicylic Acid

Base Information

• Chemical Name: 5-bromo-3-phenyl Salicylic Acid
• CAS No.: 99514-99-5
• Molecular Formula: C₁₃H₉BrO₃
• Molecular Weight: 293.117
• Mol file: 99514-99-5.mol

Synonyms:5-bromo-3-phenyl Salicylic Acid

Chemical Property of 5-bromo-3-phenyl Salicylic Acid

Chemical Property:

• Boiling Point: 416.9±45.0 °C(Predicted)
• PKA: 2.38±0.14(Predicted)
• PSA: 57.53000
• Density: 1.611±0.06 g/cm3(Predicted)
• LogP: 3.51990

Purity/Quality:

99% ^*data from raw suppliers

5-bromo-3-phenyl Salicylic Acid ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-3-phenyl Salicylic Acid

There total 2 articles about 5-bromo-3-phenyl Salicylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

methyl 5-bromo-2-methoxybiphenyl-3-carboxylate (1155261-82-7) → 3-phenyl-5-bromosalicylic acid (99514-99-5)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 ℃; Inert atmosphere;

DOI:10.1021/jm9001633

Reference yield:

3-phenylsalicylic acid (304-06-3) → 3-phenyl-5-bromosalicylic acid (99514-99-5)

Guidance literature:

With bromine; acetic acid;

Reference yield:

3-phenyl-5-bromosalicylic acid (99514-99-5) + 2-(diethylamino)ethyl chloride (100-35-6) → 5-bromo-2-hydroxy-biphenyl-3-carboxylic acid-(2-diethylamino-ethyl ester); hydrochloride (6284-60-2)

Guidance literature:

upstream raw materials:

3-phenylsalicylic acid

methyl 5-bromo-2-methoxybiphenyl-3-carboxylate

Downstream raw materials:

5-bromo-2-hydroxy-biphenyl-3-carboxylic acid-(2-diethylamino-ethyl ester); hydrochloride

5-bromo-2-hydroxy-biphenyl-3-carboxylic acid-(2-diisopropylamino-ethyl ester); hydrochloride

5-bromo-2-methoxy-biphenyl-3-carboxylic acid methylamide

5-bromo-2-(2-hydroxy-ethoxy)-biphenyl-3-carboxylic acid-(2-hydroxy-ethylamide)

Refernces