3,3',5,5'-Tetraisopropylbiphenyl-4,4'-diol

Base Information

• Chemical Name: 3,3',5,5'-Tetraisopropylbiphenyl-4,4'-diol
• CAS No.: 2416-95-7
• Molecular Formula: C24H34 O2
• Molecular Weight: 354.533
• Hs Code.: 2907299090
• Mol file: 2416-95-7.mol

Synonyms:p,p'-Biphenol,2,2',6,6'-tetraisopropyl- (6CI,7CI,8CI);3,3',5,5'-Tetraisopropyl-4,4'-dihydroxybiphenyl; Dipropofol

Chemical Property of 3,3',5,5'-Tetraisopropylbiphenyl-4,4'-diol

Chemical Property:

• Melting Point: 107.0 to 111.0 °C
• Boiling Point: 451.9±45.0 °C(Predicted)
• PKA: 10.54±0.40(Predicted)
• PSA: 40.46000
• Density: 1.007±0.06 g/cm3(Predicted)
• LogP: 7.25840
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dipropofol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dipropofol is a dimeric derivative of Propofol (P829750). Dipropofol is an antibacterial agent with strong activity againts Gram-positive bacteria. Dipropofol also displays antioxidant and radical sca venging activity. Dipropofol (Propofol EP Impurity E) is a dimeric derivative of Propofol (P829750). Dipropofol is an antibacterial agent with strong activity againts Gram-positive bacteria. Dipropofol also displays antioxidant and radical scavenging activity. Propofol USP Related Compound A.

Technology Process of 3,3',5,5'-Tetraisopropylbiphenyl-4,4'-diol

There total 10 articles about 3,3',5,5'-Tetraisopropylbiphenyl-4,4'-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-diisopropylphenol (2078-54-8) → 3,3',5,5'-tetraisopropyl-[1,1'-biphenyl]-4,4'-diol (2416-95-7)

Guidance literature:

2,6-diisopropylphenol; With oxygen; In tert-butyl alcohol; at 70 ℃; for 18h; under 760.051 Torr; Green chemistry;

With hydrogen; In tert-butyl alcohol; at 60 ℃; for 4h; under 760.051 Torr; Green chemistry;

DOI:10.1039/c7cy00919d

Reference yield: 24.0%

2,6-diisopropylphenol (2078-54-8) → 3,3',5,5'-tetraisopropyldiphenoquinone (2178-51-0) + 3,3',5,5'-tetraisopropyl-[1,1'-biphenyl]-4,4'-diol (2416-95-7)

Guidance literature:

With manganese(III) acetylacetonate; In acetic acid; for 0.0166667h; Ambient temperature;

DOI:10.1246/bcsj.65.620

Reference yield: 1.0%

2,6-diisopropylphenol (2078-54-8) → 3,3',5,5'-tetraisopropyldiphenoquinone (2178-51-0) + 3,3',5,5'-tetraisopropyl-[1,1'-biphenyl]-4,4'-diol (2416-95-7) + Acetic acid 4-hydroxy-3,5-diisopropyl-phenyl ester (22944-23-6)

Guidance literature:

With manganese triacetate; In acetic acid; at 100 ℃; for 0.0833333h;

DOI:10.1246/bcsj.65.620

upstream raw materials:

3,3',5,5'-tetraisopropyldiphenoquinone

2,6-diisopropylphenol

1,3-diisopropylbenzene

4-hydroxy-benzoic acid

Downstream raw materials:

3,3',5,5'-tetraisopropyldiphenoquinone

Refernces

• 1、 -. "THE USE OF DIPHENOL IN PREPARATION OF MEDICINES FOR PREVENTION AND TREATMENT OF CEREBRAL ISCHEMIA". . . Retrieved 2018/07/29.
• 2、 Lee, Young Eun,Cao, Trung,Torruellas, Carilyn,Kozlowski, Marisa C.. "Selective oxidative homo-and cross-coupling of phenols with aerobic catalysts". supporting information. p. 6782 - 6785. Retrieved 2014/06/09.