2,4-difluoro-6-iodophenol

Base Information

• Chemical Name: 2,4-difluoro-6-iodophenol
• CAS No.: 551002-42-7
• Molecular Formula: C6H3F2IO
• Molecular Weight: 255.991
• Mol file: 551002-42-7.mol

Synonyms:2,4-difluoro-6-iodophenol

Chemical Property of 2,4-difluoro-6-iodophenol

Chemical Property:

• PSA: 20.23000
• LogP: 2.27500
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluoro-6-iodophenol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-difluoro-6-iodophenol

There total 2 articles about 2,4-difluoro-6-iodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4-difluorophenol (367-27-1) → 4,6-difluoro-2-iodo-phenol (551002-42-7)

Guidance literature:

With iodine; sodium hydrogencarbonate; In water; at 20 ℃; for 24h;

DOI:10.1016/j.jfluchem.2019.109371

Reference yield: 41.16%

sodium hypochlorite (7681-52-9) + 2,4-difluorophenol (367-27-1) → 4,6-difluoro-2-iodo-phenol (551002-42-7)

Guidance literature:

In methanol; dichloromethane;

Reference yield: 98.0%

4,6-difluoro-2-iodo-phenol (551002-42-7) + tris-iso-propylsilyl acetylene (89343-06-6) → 2,4-difluoro-6-((triisopropylsilyl)ethynyl)phenol

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 20 ℃; for 48h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.jfluchem.2019.109435

upstream raw materials:

2,4-difluorophenol

sodium hypochlorite

Downstream raw materials:

5,7-Difluoro-2-(4-methoxy-phenyl)-benzofuran

2,4-difluoro-6-iodoanisole

1,3-bis(2,4-difluoro-6-iodophenoxy)propane

Refernces

• 1、 Politanskaya, Larisa,Troshkova, Nadezhda,Tretyakov, Evgeny,Xi, Chanjuan. "Synthesis of polyfluorinated benzofurans". . . Retrieved 2019/09/18.
• 2、 -. "PROCESS FOR SELECTIVELY POLYMERIZING ETHYLENE AND CATALYST THEREFOR". Page/Page column. . Retrieved 2013/03/26.