2,4-Dihydroxy-5-isopropylbenzoic acid

Base Information

• Chemical Name: 2,4-Dihydroxy-5-isopropylbenzoic acid
• CAS No.: 1184181-48-3
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Mol file: 1184181-48-3.mol

Synonyms:2,4-Dihydroxy-5-isopropylbenzoic acid

Chemical Property of 2,4-Dihydroxy-5-isopropylbenzoic acid

Chemical Property:

• Boiling Point: 395.2±27.0 °C(Predicted)
• PKA: 3.48±0.10(Predicted)
• PSA: 77.76000
• Density: 1.317±0.06 g/cm3(Predicted)
• LogP: 1.91940
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

2,4-Dihydroxy-5-isopropylbenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Dihydroxy-5-isopropylbenzoic acid

There total 6 articles about 2,4-Dihydroxy-5-isopropylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-dihydroxy-5-isopropylbenzoic acid methyl ester (943519-37-7) → 2,4-dihydroxy-5- isopropylbenzoic acid (1184181-48-3)

Guidance literature:

With lithium hydroxide; In methanol; water; at 50 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.10.038

Reference yield: 85.0%

carbon dioxide (124-38-9,18923-20-1) + 2,4-dihydroxy-1-isopropylbenzene (23504-03-2) → 2,4-dihydroxy-5- isopropylbenzoic acid (1184181-48-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 30 ℃; for 24h; under 15001.5 Torr; Autoclave;

DOI:10.1039/c9cc04550c

Reference yield:

4-hydroxysalicylic acid (89-86-1) → 2,4-dihydroxy-5- isopropylbenzoic acid (1184181-48-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 24 h / 100 °C / Inert atmosphere

2: aluminum (III) chloride / dichloromethane / 24 h / 50 °C / Inert atmosphere

3: lithium hydroxide / methanol; water / 12 h / 50 °C / Inert atmosphere

With aluminum (III) chloride; sulfuric acid; lithium hydroxide; In methanol; dichloromethane; water; 2: |Friedel-Crafts Alkylation;

DOI:10.1016/j.ejmech.2016.10.038

upstream raw materials:

4-hydroxysalicylic acid

methyl 2,4-dihydroxybenzoate

2,4-dihydroxy-5-isopropylbenzoic acid methyl ester

carbon dioxide

Refernces

• 1、 -. "ISOINDOLINE DERIVATIVES WHICH BIND TO AN ATP BINDING SITE". . . Retrieved 2021/07/31.
• 2、 Sadamitsu, Yuta,Okumura, Akira,Saito, Kodai,Yamada, Tohru. "Kolbe-Schmitt type reaction under ambient conditions mediated by an organic base". supporting information. p. 9837 - 9840. Retrieved 2019/08/20.