tert-Butyl 4-vinylcyclohexylcarbaMate

Base Information

• Chemical Name: tert-Butyl 4-vinylcyclohexylcarbaMate
• CAS No.: 1198355-16-6
• Molecular Formula: C13H23NO2
• Molecular Weight: 225.331
• Mol file: 1198355-16-6.mol

Synonyms:tert-Butyl 4-vinylcyclohexylcarbaMate;trans-1-(Boc-aMino)-4-vinylcyclohexane, 97%;tert-butyl Trans-4-vinylcyclohexylcarbaMate;tert-butyl N-[trans-4-ethenylcyclohexyl]carbamate

Chemical Property of tert-Butyl 4-vinylcyclohexylcarbaMate

Chemical Property:

• PSA: 38.33000
• LogP: 3.64680
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl(trans-4-Vinylcyclohexyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: trans-1-(Boc-amino)-4-vinylcyclohexane used as a intermediate in pharmaceutical.

Technology Process of tert-Butyl 4-vinylcyclohexylcarbaMate

There total 2 articles about tert-Butyl 4-vinylcyclohexylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

trans-(4-formyl-cyclohexyl)-carbamic acid tert-butyl ester (181308-57-6) + Methyltriphenylphosphonium bromide (1779-49-3) → tert-butyl ((trans)-4-vinylcyclohexyl)carbamate (1198355-16-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

→ tert-butyl ((trans)-4-vinylcyclohexyl)carbamate (1198355-16-6)

Guidance literature:

Reference yield: 92.0%

tert-butyl ((trans)-4-vinylcyclohexyl)carbamate (1198355-16-6) → [4-((2R)-1,2-dihydroxyethyl)cyclohexyl]carbamic acid tert-butyl ester

Guidance literature:

With potassium carbonate; potassium hexacyanoferrate(III); potassium osmate(VI) dihydrate; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; In water; tert-butyl alcohol; at 0 ℃; for 30h;

upstream raw materials:

trans-(4-formyl-cyclohexyl)-carbamic acid tert-butyl ester

Methyltriphenylphosphonium bromide

Downstream raw materials:

tert-butyl (1R,4r)-4-[(R)-1-(2-nitrophenylsulfonyl)aziridin-2-yl]cyclohexylcarbamate

Refernces

• 1、 -. "Isoxazolines as Therapeutic Agents". Paragraph 0909. . Retrieved 2013/03/26.
• 2、 -. "[4-(1-AMINO-ETHYL) -CYCLOHEXYL] -METHYL-AMINE AND [6-(1-AMINO-ETHYL) -TETRAHYDRO- PYRAN-3-YL] -METHYL-AMINE DERIVATIVES AS ANTIBACTERIALS". Page/Page column 36-37. . Retrieved 2009/12/28.