2-Bromo-5-(methylsulphonyl)aniline

Base Information

• Chemical Name: 2-Bromo-5-(methylsulphonyl)aniline
• CAS No.: 942474-24-0
• Molecular Formula: C7H8BrNO2S
• Molecular Weight: 250.116
• Hs Code.: 2921420090
• Mol file: 942474-24-0.mol

Synonyms:2-Bromo-5-(methylsulphonyl)aniline;3-Amino-4-bromophenyl methyl sulphone

Chemical Property of 2-Bromo-5-(methylsulphonyl)aniline

Chemical Property:

• Melting Point: 117-118
• PSA: 68.54000
• LogP: 3.09680
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromo-5-(methylsulfonyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-5-(methylsulphonyl)aniline

There total 1 articles about 2-Bromo-5-(methylsulphonyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-(methylsulfonyl)-2-nitrobenzene (94832-06-1) → 2-bromo-5-(methylsulfonyl)aniline (942474-24-0)

Guidance literature:

With hydrogenchloride; iron; In ethanol; for 24h; Reflux;

Reference yield: 95.0%

2-bromo-5-(methylsulfonyl)aniline (942474-24-0) + 2-(5-fluoro-thiophen-2-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane → 2-(5-fluorothiophen-2-yl)-5-(methylsulfonyl)aniline

Guidance literature:

With potassium phosphate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); In 1,4-dioxane; water; at 80 ℃; for 0.583333h; Inert atmosphere;

Reference yield: 78.0%

6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (865245-32-5) + 2-bromo-5-(methylsulfonyl)aniline (942474-24-0) → tert-butyl 6-(2-amino-4-(methylsulfonyl)phenyl)-3,4-dihydropyridine-1-carboxylate

Guidance literature:

With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; at 80 ℃; for 1h; Inert atmosphere;

upstream raw materials:

1-bromo-4-(methylsulfonyl)-2-nitrobenzene

Downstream raw materials:

tert-butyl 2-bromo-5-(methylsulfonyl)phenylcarbamate

tert-butyl 5-(methylsulfonyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate

Refernces

• 1、 -. "COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS". Page/Page column 169-170. . Retrieved 2009/10/22.