3-(benzyloxy)-6-chloro-2-iodopyridine

Base Information

• Chemical Name: 3-(benzyloxy)-6-chloro-2-iodopyridine
• CAS No.: 690261-53-1
• Molecular Formula: C₁₂H₉ClINO
• Molecular Weight: 345.567
• Mol file: 690261-53-1.mol

Synonyms:3-(benzyloxy)-6-chloro-2-iodopyridine

Chemical Property of 3-(benzyloxy)-6-chloro-2-iodopyridine

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(benzyloxy)-6-chloro-2-iodopyridine

There total 1 articles about 3-(benzyloxy)-6-chloro-2-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + 6-chloro-2-iodopyridine-3-ol (188057-26-3) → 3-(benzyloxy)-6-chloro-2-iodopyridine (690261-53-1)

Guidance literature:

With silver carbonate; In toluene; for 1h; Heating / reflux;

Reference yield: 90.0%

3-(benzyloxy)-6-chloro-2-iodopyridine (690261-53-1) + propargyl alcohol (107-19-7) → 3-(3-(benzyloxy)-6-chloropyridin-2-yl)prop-2-yn-1-ol (1427035-17-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 6h;

Reference yield:

3-(benzyloxy)-6-chloro-2-iodopyridine (690261-53-1) + (2-bromophenyl)boronic acid (244205-40-1) → 2-(2-bromophenyl)-6-chloro-3-[(phenylmethyl)-oxy]-pyridine (690261-54-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 90 ℃; for 2h; Heating / reflux;

upstream raw materials:

benzyl bromide

6-chloro-2-iodopyridine-3-ol

Downstream raw materials:

2-(2-bromophenyl)-6-chloro-3-[(phenylmethyl)-oxy]-pyridine

(2-(3-(benzyloxy)-6-chloropyridin-2-yl)pyrazolo[1,5-a]pyridin-3-yl)methanol

5-(5-(benzyloxy)-6-(3-(hydroxymethyl)pyrazolo[1,5-a]pyridin-2-yl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

2-(4-fluorophenyl)-5-(5-hydroxy-6-(3-(hydroxymethyl)pyrazolo[1,5-a]pyridin-2-yl)pyridin-2-yl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Refernces