rac 5-Desfluoro Voriconazole

Base Information

• Chemical Name: rac 5-Desfluoro Voriconazole
• CAS No.: 182369-73-9
• Molecular Formula: C₁₆H₁₅F₂N₅O
• Molecular Weight: 331.325
• Hs Code.: 2933998350
• Mol file: 182369-73-9.mol

Synonyms:rac 5-Desfluoro Voriconazole ;(+/-)-DesMonofluono Voriconazole;(R*,S*)-α-(2,4-Difluorophenyl)-β-Methyl-α-(1H-1,2,4-triazol-1-ylMethyl)-4-pyriMidineethanol;Voriconazole IMpurity B;(2RS,3SR)-2-(2,4-Difluorophenyl)-3-pyrimidin-4-yl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Chemical Property of rac 5-Desfluoro Voriconazole

Chemical Property:

• Boiling Point: 513.3±60.0 °C(Predicted)
• PKA: 11.76±0.29(Predicted)
• PSA: 76.72000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 2.03780

Purity/Quality:

97% ^*data from raw suppliers

rac 5-Desfluoro Voriconazole| ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Voriconazole

Technology Process of rac 5-Desfluoro Voriconazole

There total 8 articles about rac 5-Desfluoro Voriconazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(4-chloropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (188416-44-6) → 2-(2,4-difluorophenyl)-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (182369-73-9)

Guidance literature:

With methanol; palladium on activated charcoal; ammonium formate; for 5h; Reflux;

Reference yield:

(2R,3R/2S,3S)-3-(4-chloropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol → (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (129793-37-9,182369-73-9)

Guidance literature:

With ammonium formate; palladium; In methanol; dichloromethane;

Reference yield:

1,2,4-Triazole (288-88-0) + (-)-(2R,3S)-2-(2,4-Difluorophenyl)-3-(pyrimidin-4-yl)butan-1,2-diol + methanesulfonyl chloride (124-63-0) → (2R,3S)-2-(2,4-difluorophenyl)-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (182369-73-9)

Guidance literature:

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

upstream raw materials:

4-ethylpyrimidine

1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

n-butyllithium

3-(4-chloropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Refernces

• 1、 -. "Preparation of triazoles by organometallic addition to ketones and intermediates therefor". . . Retrieved 2008/06/13.
• 2、 -. "Triazole antifungal agents". . . Retrieved 2008/06/13.