5-(2-Methyl-1,3-dioxolan-2-yl)valeric acid ethyl ester

Base Information

• Chemical Name: 5-(2-Methyl-1,3-dioxolan-2-yl)valeric acid ethyl ester
• CAS No.: 36651-17-9
• Molecular Formula: C₁₁H₂₀O₄
• Molecular Weight: 216.277
• Mol file: 36651-17-9.mol

Synonyms:5-(2-Methyl-1,3-dioxolan-2-yl)valeric acid ethyl ester

Chemical Property of 5-(2-Methyl-1,3-dioxolan-2-yl)valeric acid ethyl ester

Chemical Property:

• PSA: 44.76000
• LogP: 1.87290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-Methyl-1,3-dioxolan-2-yl)valeric acid ethyl ester

There total 3 articles about 5-(2-Methyl-1,3-dioxolan-2-yl)valeric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

ethyl 6-oxoheptanoate (30956-41-3) + ethylene glycol (107-21-1) → ethyl 5-(2-methyl-1,3-dioxolan-2-yl)pentanoate (36651-17-9)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 23h; Reflux; Dean-Stark;

DOI:10.1002/anie.201606792

Reference yield:

2-acetylcyclopentanaone (1670-46-8) → ethyl 5-(2-methyl-1,3-dioxolan-2-yl)pentanoate (36651-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: iron(III) chloride / 16 h / 80 °C

2: toluene-4-sulfonic acid / toluene / 23 h / Reflux; Dean-Stark

With iron(III) chloride; toluene-4-sulfonic acid; In toluene;

DOI:10.1002/anie.201606792

Reference yield:

→ ethyl 5-(2-methyl-1,3-dioxolan-2-yl)pentanoate (36651-17-9)

Guidance literature:

aus dem entspr. Ketoester, Aethylenglykol;

DOI:10.1021/ja00757a025

upstream raw materials:

ethyl 6-oxoheptanoate

ethylene glycol

2-acetylcyclopentanaone

Downstream raw materials:

5-(2-methyl-[1,3]dioxolan-2-yl)-pentan-1-ol

Refernces

• 1、 Shindo, Mitsuru,Matsumoto, Kenji,Sato, Yusuke,Shishido, Kozo. "The First Tandem [2 + 2] Cycloaddition-Michael Reaction Using Ynolates: Facile Construction of Substituted Carbocycles". . p. 2029 - 2030. Retrieved 2007/10/03.