N-ForMylsaccharin

Base Information

• Chemical Name: N-ForMylsaccharin
• CAS No.: 50978-45-5
• Molecular Formula: C8H5NO4S
• Molecular Weight: 211.198
• Hs Code.: 2925199590
• Mol file: 50978-45-5.mol

Synonyms:N-ForMylsaccharin

Chemical Property of N-ForMylsaccharin

Chemical Property:

• Boiling Point: 418.3±28.0 °C(Predicted)
• PKA: -21.17±0.20(Predicted)
• PSA: 79.90000
• Density: 1.771±0.06 g/cm3(Predicted)
• LogP: 1.64210
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DCM

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Formylsaccharin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Formylsaccharin is an reagent that was shown to be efficient at chemoselective N-formylation of both primary and secondary amines.

Technology Process of N-ForMylsaccharin

There total 3 articles about N-ForMylsaccharin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

saccharin (81-07-2) + formyl acetic anhydride (2258-42-6) → 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide (50978-45-5)

Guidance literature:

at 60 ℃; for 5h;

DOI:10.1055/s-0030-1260951

Reference yield: 84.0%

acetic anhydride (108-24-7) + saccharin (81-07-2) → 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide (50978-45-5)

Guidance literature:

acetic anhydride; With formic acid; at 55 ℃; for 2h; Inert atmosphere;

saccharin; at 60 ℃; for 5h; Inert atmosphere;

Reference yield:

saccharin (81-07-2) + formyl acetic anhydride (2258-42-6) → N-acetyl saccharin (13361-42-7) + 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide (50978-45-5)

Guidance literature:

at 60 ℃; Overall yield = 5.1 g; Inert atmosphere; Schlenk technique;

DOI:10.1039/c5cc05012j

upstream raw materials:

saccharin

formyl acetic anhydride

acetic anhydride

Downstream raw materials:

N-Formylpiperidine

4-morpholinecarboxaldehyde

N-formyl-4-hydroxypiperidine

1,1-dimethylpropyl-formamide

Refernces

• 1、 Gehrtz,Hirschbeck,Fleischer. "A recyclable CO surrogate in regioselective alkoxycarbonylation of alkenes: Indirect use of carbon dioxide". supporting information. p. 12574 - 12577. Retrieved 2015/08/06.