2-Chloro-4,5-dimethyl-thiazole

Base Information

• Chemical Name: 2-Chloro-4,5-dimethyl-thiazole
• CAS No.: 56355-41-0
• Molecular Formula: C5H6ClNS
• Molecular Weight: 147.628
• Hs Code.: 2934100090
• Mol file: 56355-41-0.mol

Synonyms:2-Chloro-4,5-dimethyl-thiazole

Chemical Property of 2-Chloro-4,5-dimethyl-thiazole

Chemical Property:

• PSA: 41.13000
• LogP: 2.41330

Purity/Quality:

99% ^*data from raw suppliers

2-chloro-4,5-dimethyl-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4,5-dimethyl-thiazole

There total 7 articles about 2-Chloro-4,5-dimethyl-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

4,5-dimethyl-1,3-thiazole 3-oxide (141305-45-5) → 4-methyl-5-thiazolylmethyl chloride (10014-52-5) + 2-chloro-4,5-dimethyl-1,3-thiazole (56355-41-0) + 4-chloromethyl-5-methylthiazole hydrochloride (141305-55-7) + 4-chloromethyl-5-methylthiazole (141305-54-6)

Guidance literature:

With acetyl chloride; for 6h;

Reference yield:

3-thiocyanobutan-2-one (57308-65-3) → 2-chloro-4,5-dimethyl-1,3-thiazole (56355-41-0)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01127a032

Reference yield:

4,5-dimethyl-thiazole-2-diazonium; tetrafluoroborate → 2-chloro-4,5-dimethyl-1,3-thiazole (56355-41-0)

Guidance literature:

With copper(l) chloride; lithium chloride; at -5 ℃;

upstream raw materials:

3-thiocyanobutan-2-one

4,5-dimethyl-1,3-thiazole 3-oxide

4,5-dimethyl-3H-thiazol-2-one

hydrogenchloride

Downstream raw materials:

4-{2-[(4,5-Dimethyl-thiazol-2-yl)-methyl-amino]-ethoxy}-benzaldehyde

4,5-dimethyl-N-phenylthiazol-2-amine

ethyl 2-chloro-4-methylthiazole-5-carboxylate

4,5,4',5'-tetramethyl-2,2'-sulfanediyl-bis-thiazole

Refernces

• 1、 Begtrup, Mikael,Hansen, Lars Bo L.. "New Methods for the Introduction of Substituents into Thiazoles". . p. 372 - 383. Retrieved 2007/10/02.