(1R)-1-(thiophen-2-yl)ethan-1-amine

Base Information

• Chemical Name: (1R)-1-(thiophen-2-yl)ethan-1-amine
• CAS No.: 22038-88-6
• Molecular Formula: C6H9NS
• Molecular Weight: 127.21
• DSSTox Substance ID: DTXSID001291995
• Nikkaji Number: J77.171F
• Mol file: 22038-88-6.mol

Synonyms:(1R)-1-(thiophen-2-yl)ethan-1-amine;22038-88-6;(1R)-1-(2-thienyl)ethylamine;(1R)-1-thiophen-2-ylethanamine;MFCD09822150;(R)-1-(2-thienyl)ethylamine;SCHEMBL15476824;DTXSID001291995;(R)-1-(thiophen-2-yl)ethanamine;XAA03888;[R,(+)]-alpha-Methyl-2-thenylamine;AKOS017463681;(R)-1-(Thiophen-2-yl)ethan-1-amine;AS-59536;(alphaR)-alpha-Methyl-2-thiophenemethanamine;CS-0158748;EN300-89279;N12970

Chemical Property of (1R)-1-(thiophen-2-yl)ethan-1-amine

Chemical Property:

• Boiling Point: 195.5±15.0 °C(Predicted)
• PKA: 9.42±0.29(Predicted)
• PSA: 54.26000
• Density: 1.095±0.06 g/cm3(Predicted)
• LogP: 2.46810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 127.04557046
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

99% ^*data from raw suppliers

(1R)-1-(thiophen-2-yl)ethan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CC=CS1)N
• Isomeric SMILES: C[C@H](C1=CC=CS1)N

Technology Process of (1R)-1-(thiophen-2-yl)ethan-1-amine

There total 14 articles about (1R)-1-(thiophen-2-yl)ethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(R)-2-methyl-N-((R)-1-(thiophen-2-yl)ethyl)propane-2-sulfinamide → (R)-1-(thiophen-2-yl)ethanamine (22038-88-6)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.15227/orgsyn.090.0338

Reference yield: 85.0%

2-Acetylthiophene (88-15-3,97511-16-5) → 1-thiophen-2-yl-ethylamine (6309-16-6,22038-88-6)

Guidance literature:

With formic acid; C₂₆H₃₄ClIrN₄O; ammonium formate; In methanol; at 80 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.9b01565

Reference yield: 14.0%

2-acetylthiophene oxime (1956-45-2,92313-45-6,92313-54-7) → 1-thiophen-2-yl-ethylamine (6309-16-6,22038-88-6)

Guidance literature:

With hydrogenchloride; copper(II) sulfate; zinc; In ethanol; water; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2021.113190

upstream raw materials:

2-Acetylthiophene

2-acetylthiophene oxime

N-(R)-(1-(thiophen-2-yl)ethyl)acetamide

1-thiophen-2-yl-ethylamine

Downstream raw materials:

2-Acetylthiophene

Refernces

• 1、 Biselli, Sabrina,Bresinsky, Merlin,Buschauer, Armin,Forster, Lisa,Honisch, Claudia,Pockes, Steffen,Tropmann, Katharina,Bernhardt, Günther. "Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H2R and D3R". supporting information. . Retrieved 2021/02/12.
• 2、 Tanaka, Kouichi,Miki, Takashi,Murata, Kunihiko,Yamaguchi, Ayumi,Kayaki, Yoshihito,Kuwata, Shigeki,Ikariya, Takao,Watanabe, Masahito. "Reductive amination of ketonic compounds catalyzed by Cp*Ir(III) complexes bearing a picolinamidato ligand". . p. 10962 - 10977. Retrieved 2019/09/03.