2-Chloro-4-isopropoxyaniline

Base Information

• Chemical Name: 2-Chloro-4-isopropoxyaniline
• CAS No.: 1071989-24-6
• Molecular Formula: C₉H₁₂ClNO
• Molecular Weight: 185.653
• Mol file: 1071989-24-6.mol

Synonyms:2-Chloro-4-isopropoxyaniline

Chemical Property of 2-Chloro-4-isopropoxyaniline

Chemical Property:

• Boiling Point: 273.7±20.0 °C(Predicted)
• Density: 1.152±0.06 g/cm3(Predicted)

Purity/Quality:

≥99% ^*data from raw suppliers

2-Chloro-4-(propan-2-yloxy)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-4-isopropoxyaniline

There total 3 articles about 2-Chloro-4-isopropoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(3-chloro-4-nitro-phenyl)-isopropyl ether (40422-91-1) → 2-chloro-4-isopropoxy-phenylamine (1071989-24-6)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 80 ℃; for 2h;

Reference yield: 73.0%

4-amino-3-chlorophenol (17609-80-2) + isopropyl bromide (75-26-3) → 2-chloro-4-isopropoxy-phenylamine (1071989-24-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 80 ℃; Inert atmosphere;

Reference yield:

2-chloro-4-fluoro-1-nitrobenzene (2106-50-5) → 2-chloro-4-isopropoxy-phenylamine (1071989-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 8 h / 40 °C

2: iron; ammonium chloride / water; ethanol / 2 h / 80 °C

With iron; ammonium chloride; caesium carbonate; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

4-amino-3-chlorophenol

isopropyl bromide

2-chloro-4-fluoro-1-nitrobenzene

(3-chloro-4-nitro-phenyl)-isopropyl ether

Refernces

• 1、 -. "OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE". . . Retrieved 2020/11/30.