(2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE

Base Information

• Chemical Name: (2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE
• CAS No.: 91973-39-6
• Molecular Formula: C12H10N2O
• Molecular Weight: 198.224
• Hs Code.: 2933399090
• Mol file: 91973-39-6.mol

Synonyms:(2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE

Chemical Property of (2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE

Chemical Property:

• Melting Point: 160-161 °C
• Boiling Point: 412.9±25.0 °C(Predicted)
• PKA: 2.66±0.10(Predicted)
• PSA: 55.98000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 2.47600
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

(2-Amino-phenyl)-pyridin-4-yl-methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE

There total 19 articles about (2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C17H18N2O3 (280568-14-1) → (2-Aminophenyl)-(pyridin-4-yl)methanone (91973-39-6)

Guidance literature:

With methanol; acetyl chloride;

Reference yield: 83.0%

N-(2-isonicotinoylphenyl)-2,2-dimethylpropanamide (126971-80-0) → (2-Aminophenyl)-(pyridin-4-yl)methanone (91973-39-6)

Guidance literature:

With hydrogenchloride; In ethanol; for 8h; Reflux;

Reference yield: 69.2%

(2-nitrophenyl)-(4-pyridyl)methanone (115177-76-9) → (2-Aminophenyl)-(pyridin-4-yl)methanone (91973-39-6) + 2-aminophenyl(4-pyridyl)-methanol (115177-60-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

upstream raw materials:

(2-nitrophenyl)-(4-pyridyl)methanone

pyridine-4-carbaldehyde

N-pivaloylaniline

N-(2-isonicotinoylphenyl)-2,2-dimethylpropanamide

Downstream raw materials:

C₂₂H₂₅N₃O₄

N-(4-{[(2-isonicotinoylphenyl)amino]sulfonyl}phenyl)acetamide

(1-Methyl-2-oxo-5-pyridin-4-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester

{Amino-[2-(pyridine-4-carbonyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester

Refernces

• 1、 Zhu, Xiaolin,Wang, Danfeng,Huang, Hai,Zhang, Xueqiong,Wang, Shifan,Liu, Rui,Zhu, Hongjun. "Design, synthesis, crystal structures, and photophysical properties of tetraphenylethene-based quinoline derivatives". . . Retrieved 2019/07/09.
• 2、 -. "Azacycloheptane-o-diazepine drug molecule with antitumor activity and preparation method thereof". Paragraph 0045; 0046. . Retrieved 2018/03/24.