NA

Base Information

• Chemical Name: NA
• CAS No.: 34818-49-0
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.204
• Mol file: 34818-49-0.mol

Synonyms:

Chemical Property of NA

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NA

There total 2 articles about NA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

methanol (67-56-1) + isochromane (493-05-0) → isochroman-1-one (4702-34-5) + 1-methoxyisochromane (34818-49-0)

Guidance literature:

With palladium 10% on activated carbon; oxygen; N-ethyl-N,N-diisopropylamine; at 80 ℃; for 24h;

DOI:10.1002/chem.201702278

Reference yield:

α-chloroisochroman (31253-52-8) + ketene t-butyldimethylsilyl methyl acetal (77086-38-5) → bis(3,4-dihydro-1H-benzopyran-1-yl) ether (19275-61-7) + 1-methoxyisochromane (34818-49-0) + 1-Isochroman-essigsaeuremethylester (163277-63-2)

Guidance literature:

α-chloroisochroman; With C₃₇H₄₅F₃I₂N₄⁽²⁺⁾*2CF₃O₃S^(1-); In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere; Schlenk technique;

ketene t-butyldimethylsilyl methyl acetal; In tetrahydrofuran; at -78 ℃; for 118h; Reagent/catalyst; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201704502

Reference yield: 99.0%

1-methoxyisochromane (34818-49-0) + 1-(2-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-yn-1-one (767303-58-2) → 3-(isochroman-1-yl)-2-(4-methoxyphenyl)-4H-chromen-4-one

Guidance literature:

With boron trifluoride diethyl etherate; In acetonitrile; at 20 ℃; for 0.00166667h; regioselective reaction;

DOI:10.1055/s-0036-1588327

upstream raw materials:

methanol

isochromane

α-chloroisochroman

ketene t-butyldimethylsilyl methyl acetal

Downstream raw materials:

2-(β-hydroxyethyl)benzaldehyde

methyl 1-(3,4-dihydro-1H-isochromen-1-yl)cyclohexanecarboxylate

methyl 2-((R)-3,4-dihydro-1H-isochromen-1-yl)acetate

methyl 2-((S)-3,4-dihydro-1H-isochromen-1-yl)acetate

Refernces

• 1、 Wonner, Patrick,Vogel, Lukas,Kniep, Florian,Huber, Stefan M.. "Catalytic Carbon–Chlorine Bond Activation by Selenium-Based Chalcogen Bond Donors". supporting information. p. 16972 - 16975. Retrieved 2017/11/20.