1-(5-fluoropyriMidin-2-yl)ethanol

Base Information

• Chemical Name: 1-(5-fluoropyriMidin-2-yl)ethanol
• CAS No.: 905587-43-1
• Molecular Formula: C₆H₇FN₂O
• Molecular Weight: 142.133
• Mol file: 905587-43-1.mol

Synonyms:1-(5-fluoropyriMidin-2-yl)ethanol

Chemical Property of 1-(5-fluoropyriMidin-2-yl)ethanol

Chemical Property:

• PSA: 46.01000
• LogP: 0.66900
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

1-(5-Fluoropyrimidin-2-yl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-fluoropyriMidin-2-yl)ethanol

There total 2 articles about 1-(5-fluoropyriMidin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(5-fluoropyrimidin-2-yl)ethan-1-one (905587-44-2) → 1-(5-fluoropyrimidin-2-yl)ethan-1-ol (905587-43-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h;

Reference yield:

5- fluoropyrimidine-2-carbonitrile (38275-55-7) → 1-(5-fluoropyrimidin-2-yl)ethan-1-ol (905587-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 0 - 25 °C

2: sodium tetrahydroborate / methanol; diethyl ether / 0 - 25 °C

With sodium tetrahydroborate; In methanol; diethyl ether; 1: Grignard reaction;

DOI:10.1021/jm1011319

Reference yield:

1-(5-fluoropyrimidin-2-yl)ethan-1-ol (905587-43-1) → 1-(5-fluoropyrimidin-2-yl)ethanamine (905587-41-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 25 °C

2: sodium azide / N,N-dimethyl-formamide / 60 h / 18 - 25 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 25 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm1011319

upstream raw materials:

1-(5-fluoropyrimidin-2-yl)ethan-1-one

5- fluoropyrimidine-2-carbonitrile

Downstream raw materials:

1-(5-fluoropyrimidin-2-yl)ethanamine

Refernces

• 1、 Ioannidis, Stephanos,Lamb, Michelle L.,Wang, Tao,Almeida, Lynsie,Block, Michael H.,Davies, Audrey M.,Peng, Bo,Su, Mei,Zhang, Hai-Jun,Hoffmann, Ethan,Rivard, Caroline,Green, Isabelle,Howard, Tina,Pollard, Hannah,Read, Jon,Alimzhanov, Marat,Bebernitz, Geraldine,Bell, Kirsten,Ye, Minwei,Huszar, Dennis,Zinda, Michael. "Discovery of 5-chloro- N 2-[(1 S)-1-(5-fluoropyrimidin-2-yl) ethyl]- N 4-(5-methyl-1 H -pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the jak/stat pathway". experimental part. p. 262 - 276. Retrieved 2011/03/20.
• 2、 -. "PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER". Page/Page column 92-93. . Retrieved 2008/12/08.