Furo[2,3-c]pyridin-3(2H)-one hydrochloride

Base Information

• Chemical Name: Furo[2,3-c]pyridin-3(2H)-one hydrochloride
• CAS No.: 106531-51-5
• Molecular Formula: C7H5NO2.ClH
• Molecular Weight: 171.583
• European Community (EC) Number: 878-125-2
• DSSTox Substance ID: DTXSID30704463
• Mol file: 106531-51-5.mol

Synonyms:Furo[2,3-c]pyridin-3(2H)-one hydrochloride;106531-51-5;Furo[2,3-c]pyridin-3-one hydrochloride;furo[2,3-c]pyridin-3-one;hydrochloride;FURO[2,3-C]PYRIDIN-3(2H)-ONE HCL;2H,3H-furo[2,3-c]pyridin-3-one hydrochloride;Furo[2,3-c]pyridin-3(2H)-one, hydrochloride;SCHEMBL3597821;DTXSID30704463;FWVRHCYASFZWGO-UHFFFAOYSA-N;MFCD11656372;AKOS024464291;SB30455;BS-50128;CS-0196484;FT-0725976;Furo[2,3-c]pyridin-3(2H)-onehydrochloride;EN300-177435;W17205;A895774;Z1255373514;Furo[2,3-c]pyridin-3(2H)-one--hydrogen chloride (1/1)

Chemical Property of Furo[2,3-c]pyridin-3(2H)-one hydrochloride

Chemical Property:

• PSA: 39.19000
• LogP: 1.45870
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 171.0087061
• Heavy Atom Count: 11
• Complexity: 158

Purity/Quality:

98%,99%, ^*data from raw suppliers

Furo[2,3-c]pyridin-3-onehydrochloride 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(=O)C2=C(O1)C=NC=C2.Cl

Technology Process of Furo[2,3-c]pyridin-3(2H)-one hydrochloride

There total 4 articles about Furo[2,3-c]pyridin-3(2H)-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Ethyl 3-Hydroxyfuro<2,3-c>pyridine-2-carboxylate (106531-50-4) → Furo<2,3-c>pyridin-3(2H)-one hydrochloride (106531-51-5)

Guidance literature:

With hydrogenchloride; In water; for 6h; Reflux;

Reference yield:

3-hydroxyisonicotinic acid (10128-71-9) → Furo<2,3-c>pyridin-3(2H)-one hydrochloride (106531-51-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / 98percent H₂SO₄ / benzene / 48 h / Heating

2: 62 percent / K₂CO₃ anhydr. / acetone / 2 h / Heating

3: 74 percent / Na / toluene; ethanol / 6 h / Heating

4: 10percent HCl / 2.5 h / Heating

With hydrogenchloride; sulfuric acid; sodium; potassium carbonate; In ethanol; acetone; toluene; benzene;

Reference yield:

Ethyl 2-(4-Ethoxycarbonyl-3-pyridyloxy) acetate (18343-02-7) → Furo<2,3-c>pyridin-3(2H)-one hydrochloride (106531-51-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Na / toluene; ethanol / 6 h / Heating

2: 10percent HCl / 2.5 h / Heating

With hydrogenchloride; sodium; In ethanol; toluene;

upstream raw materials:

Ethyl 3-Hydroxyfuro<2,3-c>pyridine-2-carboxylate

3-hydroxyisonicotinic acid

Ethyl 2-(4-Ethoxycarbonyl-3-pyridyloxy) acetate

ethyl 3-hydroxyisonicotinate

Downstream raw materials:

2-p-Tolylfuro[2,3-c]pyridin-3-ol

3-(tert-butyldiphenylsilyloxy)furo[2,3-c]pyridine

furo<2,3-c>pyridine

2,3-Dihydrofuro<2,3-c>pyridin-3-ol

Refernces

• 1、 -. "Raf inhibitor compounds and methods of use thereof". Page/Page column 93. . Retrieved 2010/11/26.