α-Ethyl-N-methylbenzeneethanamine

Base Information

• Chemical Name: α-Ethyl-N-methylbenzeneethanamine
• CAS No.: 84952-60-3
• Molecular Formula: C₁₁H₁₇N
• Molecular Weight: 163.263
• Mol file: 84952-60-3.mol

Synonyms:α-Ethyl-N-methylbenzeneethanamine

Chemical Property of α-Ethyl-N-methylbenzeneethanamine

Chemical Property:

• Boiling Point: 226 - 230 °C
• PSA: 12.03000
• LogP: 2.61800

Purity/Quality:

99% ^*data from raw suppliers

2-Methylamino-1-phenylbutane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-Ethyl-N-methylbenzeneethanamine

There total 5 articles about α-Ethyl-N-methylbenzeneethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

benzyl ethyl ketone (1007-32-5) + methylamine (74-89-5) → 2-(methylamino)-1-phenylbutane (84952-60-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 96h;

DOI:10.1021/ml500113s

Reference yield:

benzyl ethyl ketone (1007-32-5) + methylamine hydrochloride (593-51-1) → 2-(methylamino)-1-phenylbutane (84952-60-3)

Guidance literature:

benzyl ethyl ketone; methylamine hydrochloride; With titanium(IV) isopropylate; triethylamine; In ethanol; for 3h;

With sodium tetrahydroborate; In ethanol; for 3h; Further stages.;

DOI:10.1021/jm0004547

Reference yield:

→ 2-(methylamino)-1-phenylbutane (84952-60-3)

Guidance literature:

With perchloric acid; palladium; acetic acid; at 80 ℃; Hydrogenation;

upstream raw materials:

N-Methylformamide

benzyl ethyl ketone

formaldehyd

1-benzylpropylamine

Refernces

• 1、 Blough, Bruce E.,Landavazo, Antonio,Partilla, John S.,Baumann, Michael H.,Decker, Ann M.,Page, Kevin M.,Rothman, Richard B.. "Hybrid dopamine uptake blocker-serotonin releaser ligands: A new twist on transporter-focused therapeutics". supporting information. p. 623 - 627. Retrieved 2014/07/07.