benzimidazo(2,1-a)isoquinoline

Base Information

• Chemical Name: benzimidazo(2,1-a)isoquinoline
• CAS No.: 239-44-1
• Molecular Formula: C₁₅H₁₀N₂
• Molecular Weight: 218.258
• Mol file: 239-44-1.mol

Synonyms:benzimidazo(2,1-a)isoquinoline

Chemical Property of benzimidazo(2,1-a)isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of benzimidazo(2,1-a)isoquinoline

There total 23 articles about benzimidazo(2,1-a)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

isoquinolin-1-yl-phenyl-amine (13797-20-1) → benzo[4,5]imidazo[2,1-a]isoquinoline (239-44-1)

Guidance literature:

With Iron(III) nitrate nonahydrate; oxygen; copper diacetate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 130 ℃; for 23h;

DOI:10.1021/ja1067993

Reference yield: 91.0%

1-(benzotriazol-1-yl)isoquinoline (22244-48-0) → benzo[4,5]imidazo[2,1-a]isoquinoline (239-44-1)

Guidance literature:

at 600 ℃; under 0.01 Torr;

DOI:10.1039/b004825i

Reference yield: 83.0%

vinylene carbonate (872-36-6) + 2-phenyl-1H-benzoimidazole (716-79-0) → benzo[4,5]imidazo[2,1-a]isoquinoline (239-44-1)

Guidance literature:

With tris(acetonitrile)(η5-pentamethylcyclopentadienyl)rhodium(III) hexafluoroantimonate; In 1,2-dichloro-ethane; at 130 ℃; for 24h;

DOI:10.1021/acscatal.9b04254

upstream raw materials:

1-(benzotriazol-1-yl)isoquinoline

1,2,3,4-tetrahydro-2-(2-nitrophenyl)isoquinoline

1,2,3,4-tetrahydroisoquinoline

2-nitrophenyl bromide

Refernces

• 1、 Liu, Haiyan,Li, Zheng. "Copper-Catalyzed Construction of Benzo[4,5]imidazo[2,1- a]isoquinolines Using Calcium Carbide as a Solid Alkyne Source". supporting information. p. 8407 - 8412. Retrieved 2021/10/25.
• 2、 Ghosh, Koushik,Nishii, Yuji,Miura, Masahiro. "Rhodium-Catalyzed Annulative Coupling Using Vinylene Carbonate as an Oxidizing Acetylene Surrogate". . p. 11455 - 11460. Retrieved 2019/12/02.