2-Chloro-3-Methylisonicotinonitrile

Base Information

• Chemical Name: 2-Chloro-3-Methylisonicotinonitrile
• CAS No.: 1195189-83-3
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.581
• Hs Code.: 2933399090
• Mol file: 1195189-83-3.mol

Synonyms:2-Chloro-3-Methylisonicotinonitrile

Chemical Property of 2-Chloro-3-Methylisonicotinonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 1.91508
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-3-methylisonicotinonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-Methylisonicotinonitrile

There total 5 articles about 2-Chloro-3-Methylisonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.57%

4-cyano-3-methylpyridine-1-oxide → 2-chloro-3-methylisonicotinonitrile (1195189-83-3)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 3h;

Reference yield:

4-cyano-3-methylpyridine-1-oxide → 2-chloro-3-methylisonicotinonitrile (1195189-83-3) + 2-chloro-5-methylisonicotinonitrile

Guidance literature:

With trichlorophosphate; In dichloromethane; at 0 - 70 ℃; for 16h; Overall yield = 1.15 g;

Reference yield:

2-chloro-3-methylisonicotinic acid (133928-73-1) → 2-chloro-3-methylisonicotinonitrile (1195189-83-3)

Guidance literature:

2-chloro-3-methylisonicotinic acid; With pyridine; methanesulfonyl chloride; at 0 ℃;

With ammonia; at 20 ℃; for 1h;

upstream raw materials:

2-chloro-3-methylisonicotinic acid

3-methyl-4-cyanopyridine

Downstream raw materials:

5-(2-chloro-3-methyl-4-pyridinyl)-3-[[3-fluoro-5-(trifluoromethyl)phenyl]amino]-N,N-dimethyl-1H-pyrazole-1-propanamide

3-[[3-fluoro-5-(trifluoromethyl)phenyl]amino]-N,N-dimethyl-5-(3-methyl-4-pyridinyl)-1H-pyrazole-1-propanamide

1-(2-chloro-3-methyl-4-pyridinyl)-3-[[3-fluoro-5-(trifluoromethyl)phenyl]amino]-3-(methylthio)-2-propen-1-one

Refernces

• 1、 -. "SUBSTITUTED NITROGEN CONTAINING COMPOUNDS". Page/Page column 248. . Retrieved 2019/01/05.